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    Nek6 NIMA (never in mitosis gene a)-related expressed kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 59126, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nek6provided by MGI
    Official Full Name
    NIMA (never in mitosis gene a)-related expressed kinase 6provided by MGI
    Primary source
    MGI:MGI:1891638
    See related
    Ensembl:ENSMUSG00000026749 AllianceGenome:MGI:1891638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300007C09Rik
    Summary
    Enables protein serine/threonine kinase activity. Predicted to be involved in chromosome segregation; protein phosphorylation; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NEK6 (NIMA related kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum adult (RPKM 28.6), small intestine adult (RPKM 28.4) and 26 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nek6 in Genome Data Viewer
    Location:
    2 B; 2 24.41 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (38314052..38477502)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (38483863..38587490)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 27197 Neighboring gene STARR-seq mESC enhancer starr_04322 Neighboring gene LIM homeobox protein 2 Neighboring gene predicted gene 13584 Neighboring gene STARR-seq mESC enhancer starr_04324 Neighboring gene predicted gene, 39799 Neighboring gene predicted gene, 25081 Neighboring gene STARR-positive B cell enhancer ABC_E4444 Neighboring gene thymosin, beta 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04330 Neighboring gene predicted gene, 35808 Neighboring gene STARR-seq mESC enhancer starr_04333 Neighboring gene STARR-positive B cell enhancer mm9_chr2:38471578-38471879 Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 Neighboring gene STARR-positive B cell enhancer ABC_E4445 Neighboring gene STARR-seq mESC enhancer starr_04335 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:38499471-38499654 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04336 Neighboring gene adhesion G protein-coupled receptor D2, pseudogene Neighboring gene predicted gene, 36744

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinesin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinesin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic metaphase/anaphase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase Nek6
    Names
    NIMA-related expressed kinase 6
    never in mitosis A-related kinase 6
    nimA-related protein kinase 6
    NP_001153103.1
    NP_067619.1
    XP_006498272.1
    XP_006498273.1
    XP_030107782.1
    XP_030107783.1
    XP_030107784.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159631.1NP_001153103.1  serine/threonine-protein kinase Nek6

      See identical proteins and their annotated locations for NP_001153103.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK086700, BY205493
      Consensus CDS
      CCDS16009.1
      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Related
      ENSMUSP00000108516.2, ENSMUST00000112895.8
      Conserved Domains (1) summary
      cd08228
      Location:42309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
    2. NM_021606.3NP_067619.1  serine/threonine-protein kinase Nek6

      See identical proteins and their annotated locations for NP_067619.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AF218847, AK086700
      Consensus CDS
      CCDS16009.1
      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Related
      ENSMUSP00000049723.4, ENSMUST00000054234.10
      Conserved Domains (1) summary
      cd08228
      Location:42309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      38314052..38477502
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251924.2XP_030107784.1  serine/threonine-protein kinase Nek6 isoform X2

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
    2. XM_030251922.2XP_030107782.1  serine/threonine-protein kinase Nek6 isoform X2

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
    3. XM_030251923.2XP_030107783.1  serine/threonine-protein kinase Nek6 isoform X2

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
    4. XM_006498210.5XP_006498273.1  serine/threonine-protein kinase Nek6 isoform X2

      See identical proteins and their annotated locations for XP_006498273.1

      UniProtKB/Swiss-Prot
      Q3TCE9, Q8C6E6, Q9D0E2, Q9DBI8, Q9ES70
      UniProtKB/TrEMBL
      A2ATN9
      Conserved Domains (1) summary
      cd08228
      Location:42309
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6
    5. XM_006498209.5XP_006498272.1  serine/threonine-protein kinase Nek6 isoform X1

      Conserved Domains (1) summary
      cd08228
      Location:87354
      STKc_Nek6; Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6