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    Fsip2 fibrous sheath-interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 241516, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fsip2provided by MGI
    Official Full Name
    fibrous sheath-interacting protein 2provided by MGI
    Primary source
    MGI:MGI:2664111
    See related
    Ensembl:ENSMUSG00000075249 AllianceGenome:MGI:2664111
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to act upstream of or within with a positive effect on protein localization to cilium and sperm axoneme assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in spermatogenic failure 34. Orthologous to human FSIP2 (fibrous sheath interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 3.1) See more
    Orthologs
    NEW
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    Genomic context

    See Fsip2 in Genome Data Viewer
    Location:
    2 D; 2 49.08 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (82773978..82839281)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (82943634..83008937)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L18 pseudogene Neighboring gene calcyclin binding protein pseudogene Neighboring gene STARR-seq mESC enhancer starr_04973 Neighboring gene STARR-seq mESC enhancer starr_04974 Neighboring gene STARR-seq mESC enhancer starr_04977 Neighboring gene STARR-seq mESC enhancer starr_04978 Neighboring gene STARR-seq mESC enhancer starr_04979 Neighboring gene STARR-seq mESC enhancer starr_04980 Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 2_981.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in motile cilium IC
    Inferred by Curator
    more info
    PubMed 
    located_in sperm end piece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm end piece ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm head-tail coupling apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm head-tail coupling apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm midpiece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm midpiece ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sperm principal piece IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sperm principal piece ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    fibrous sheath-interacting protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001370266.1NP_001357195.1  fibrous sheath-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AL845500
      UniProtKB/Swiss-Prot
      A2ARZ1, A2ARZ3
      Related
      ENSMUSP00000120314.3, ENSMUST00000143764.9
      Conserved Domains (4) summary
      pfam15783
      Location:59966860
      FSIP2; Fibrous sheath-interacting protein 2
      pfam16001
      Location:56226041
      DUF4775; Domain of unknown function (DUF4775)
      pfam03154
      Location:55035649
      Atrophin-1; Atrophin-1 family
      pfam17380
      Location:136309
      DUF5401; Family of unknown function (DUF5401)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      82773978..82839281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)