Crtam cytotoxic and regulatory T cell molecule [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Crtamprovided by MGI
Official Full Name: cytotoxic and regulatory T cell moleculeprovided by MGI
Primary source: MGI:MGI:1859822
See related: Ensembl:ENSMUSG00000032021 AllianceGenome:MGI:1859822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables signaling receptor binding activity. Involved in several processes, including detection of tumor cell; establishment of T cell polarity; and regulation of T cell activation. Located in immunological synapse. Orthologous to human CRTAM (cytotoxic and regulatory T cell molecule). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 7.1) and testis adult (RPKM 4.5) See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 21.79 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (40880987..40915922, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (40972798..41004628, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Class I-restricted T cell-associated molecule (CRTAM) expression on T cells is required for an optimal IL-17 production during Toxoplasma gondii infection.
Title: CRTAM Protects Against Intestinal Dysbiosis During Pathogenic Parasitic Infection by Enabling Th17 Maturation.
These results reveal that CRTAM is critical to instruct the differentiation of CD4(+)CTL through the induction of Eomes and CTL-related gene.
Title: CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.
During pathogenic infection, Crtam-Cadm1 interactions regulate the dynamic equilibrium between newly formed CD4(+) T cells and their retention in the gut.
Title: CRTAM controls residency of gut CD4+CD8+ T cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection.
TCS upregulated the expression of tumor suppressor in lung cancer 1 (TSLC1) in 3LL tumor cells and the expression of its ligand, class I-restricted T cell-associated molecule (CRTAM), in effector T cells.
Title: Trichosanthin enhances anti-tumor immune response in a murine Lewis lung cancer model by boosting the interaction between TSLC1 and CRTAM.
In reciprocal crosses involving alcohol-preferring and alcohol-avoiding mouse strains, Crtam is identified as a candidate gene for alcohol preference.
Title: Ethanol-responsive genes (Crtam, Zbtb16, and Mobp) located in the alcohol-QTL region of chromosome 9 are associated with alcohol preference in mice.
show that CRTAM has an unexpected constitutive expression in adult thymocytes and, remarkably, it is sustained during all stages of thymocyte development.
Title: Role of CRTAM during mouse early T lymphocytes development.
CRTAM expression is critical for the accumulation of antigen-specific cytotoxic T lymphocytes and their subsequent proliferation within the draining lymph node.
Title: CRTAM confers late-stage activation of CD8+ T cells to regulate retention within lymph node.
NK cells and T8 cells recognize Necl-2 through CRTAM, expressed only on activated cells. CRTAM-Necl-2 interactions promote cytotoxicity of NK cells and IFN-gamma secretion of T8 cells as well as NK cell-mediated rejection of tumors expressing Necl-2
Title: The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM.
Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system
Title: Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Markers

AF001104 (e-PCR)
- UniSTS:159863

Crtam (e-PCR), detects polymorphism
- UniSTS:528062

Crtam (e-PCR), detects polymorphism
- UniSTS:528063

NoName (e-PCR)
- UniSTS:488697

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in cell recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell recognition	IDA Inferred from Direct Assay more info	PubMed
involved_in cell recognition	ISO Inferred from Sequence Orthology more info
involved_in cell recognition	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of tumor cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of tumor cell	ISO Inferred from Sequence Orthology more info
involved_in detection of tumor cell	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in establishment of T cell polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lymphocyte migration into lymphoid organs	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of CD8-positive, alpha-beta T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in immunological synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: cytotoxic and regulatory T-cell molecule

Names: class I-restricted T cell-associated molecule; class-I MHC-restricted T-cell-associated molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001281954.2 → NP_001268883.1 cytotoxic and regulatory T-cell molecule isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC159820

Consensus CDS

CCDS72216.1

UniProtKB/Swiss-Prot

A0A087WPL6, M0QWH9, Q149L7, Q3TQA9, Q9CVZ9, Q9Z151

UniProtKB/TrEMBL

E9QPS7

Related

ENSMUSP00000137837.2, ENSMUST00000180384.3

Conserved Domains (3) summary

smart00410
Location:22 → 112

IG_like; Immunoglobulin like

pfam08205
Location:119 → 205

C2-set_2; CD80-like C2-set immunoglobulin domain

cl11960
Location:22 → 112

Ig; Immunoglobulin domain
NM_019465.5 → NP_062338.3 cytotoxic and regulatory T-cell molecule isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC159820

Consensus CDS

CCDS40593.2

UniProtKB/TrEMBL

E9QPS7

Related

ENSMUSP00000139826.2, ENSMUST00000188848.8

Conserved Domains (3) summary

smart00410
Location:22 → 112

IG_like; Immunoglobulin like

pfam08205
Location:119 → 205

C2-set_2; CD80-like C2-set immunoglobulin domain

cl11960
Location:22 → 112

Ig; Immunoglobulin domain