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    Cct2 chaperonin containing TCP1 subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 12461, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cct2provided by MGI
    Official Full Name
    chaperonin containing TCP1 subunit 2provided by MGI
    Primary source
    MGI:MGI:107186
    See related
    Ensembl:ENSMUSG00000034024 AllianceGenome:MGI:107186
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cctb
    Summary
    Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Acts upstream of or within binding activity of sperm to zona pellucida. Located in cell body. Part of chaperonin-containing T-complex and zona pellucida receptor complex. Is expressed in central nervous system; nasal process; and somite. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 94.1), placenta adult (RPKM 81.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cct2 in Genome Data Viewer
    Location:
    10 D2; 10 65.07 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116886902..116899757, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117050997..117063852, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 10747 Neighboring gene leucine rich repeat containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E2966 Neighboring gene STARR-positive B cell enhancer ABC_E8366 Neighboring gene fibroblast growth factor receptor substrate 2 Neighboring gene STARR-seq mESC enhancer starr_27971 Neighboring gene predicted gene, 40811 Neighboring gene predicted gene, 53635

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chaperone mediated protein folding independent of cofactor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chaperone mediated protein folding independent of cofactor ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chaperone-mediated protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of establishment of protein localization to telomere ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomerase RNA localization to Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomerase RNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in scaRNA localization to Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in scaRNA localization to Cajal body ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chaperonin-containing T-complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chaperonin-containing T-complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chaperonin-containing T-complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in myelin sheath HDA PubMed 
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    T-complex protein 1 subunit beta
    Names
    CCT-beta
    TCP-1-beta
    chaperonin containing Tcp1, subunit 2 (beta)
    chaperonin subunit 2 (beta)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358767.1NP_001345696.1  T-complex protein 1 subunit beta

      Status: VALIDATED

      Source sequence(s)
      AK145406, BU755483, BY075050, CJ076140
      UniProtKB/Swiss-Prot
      P80314, Q9R1U0
      UniProtKB/TrEMBL
      Q542X7, Q9JJD8
      Conserved Domains (1) summary
      cd03336
      Location:11527
      TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    2. NM_007636.3NP_031662.2  T-complex protein 1 subunit beta

      See identical proteins and their annotated locations for NP_031662.2

      Status: VALIDATED

      Source sequence(s)
      AK145406, AL589661, BU755483
      Consensus CDS
      CCDS36067.1
      UniProtKB/Swiss-Prot
      P80314, Q9R1U0
      UniProtKB/TrEMBL
      Q542X7, Q9JJD8
      Related
      ENSMUSP00000036288.8, ENSMUST00000047672.9
      Conserved Domains (1) summary
      cd03336
      Location:11527
      TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      116886902..116899757 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)