U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sh2d6 SH2 domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 71130, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Sh2d6provided by MGI
    Official Full Name
    SH2 domain containing 6provided by MGI
    Primary source
    MGI:MGI:1918380
    See related
    Ensembl:ENSMUSG00000052631 AllianceGenome:MGI:1918380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be involved in cell surface receptor protein tyrosine kinase signaling pathway and intracellular signal transduction. Predicted to be active in cytoplasm. Orthologous to human SH2D6 (SH2 domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 14.4), duodenum adult (RPKM 4.1) and 6 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Sh2d6 in Genome Data Viewer
    Location:
    6 C1; 6 32.27 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72490624..72511180, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72513641..72534206, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2789 Neighboring gene gamma-glutamyl carboxylase Neighboring gene STARR-positive B cell enhancer ABC_E6440 Neighboring gene methionine adenosyltransferase 2A Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene STARR-seq mESC enhancer starr_16285 Neighboring gene STARR-seq mESC enhancer starr_16286 Neighboring gene STARR-seq mESC enhancer starr_16287 Neighboring gene STARR-positive B cell enhancer ABC_E11320 Neighboring gene STARR-seq mESC enhancer starr_16289 Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene capping actin protein, gelsolin like Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC118386, 4933424C13Rik

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    SH2 domain-containing protein 6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374030.1 → NP_001360959.1  SH2 domain-containing protein 6

      Status: VALIDATED

      Source sequence(s)
      AC154002
      Consensus CDS
      CCDS90061.1
      UniProtKB/TrEMBL
      A0A3Q4EGG3, E0CYY5, E2QRQ0
      Related
      ENSMUSP00000157110.2, ENSMUST00000234038.2
      Conserved Domains (1) summary
      cl15255
      Location:128 → 249
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      72490624..72511180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241547.4 → XP_011239849.1  SH2 domain-containing protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011239849.1

      Conserved Domains (1) summary
      cl15255
      Location:262 → 383
      SH2; Src homology 2 (SH2) domain

    2. XM_011241544.4 → XP_011239846.2  SH2 domain-containing protein 6 isoform X1

      Conserved Domains (1) summary
      cl15255
      Location:262 → 355
      SH2; Src homology 2 (SH2) domain

    3. XM_011241546.3 → XP_011239848.1  SH2 domain-containing protein 6 isoform X2

      See identical proteins and their annotated locations for XP_011239848.1

      Conserved Domains (1) summary
      cl15255
      Location:262 → 383
      SH2; Src homology 2 (SH2) domain

    4. XM_355785.8 → XP_355785.4  SH2 domain-containing protein 6 isoform X3

      See identical proteins and their annotated locations for XP_355785.4

      UniProtKB/Swiss-Prot
      Q497J3, Q9D413
      UniProtKB/TrEMBL
      A0A3Q4ECA8
      Related
      ENSMUSP00000157379.2, ENSMUST00000234615.2
      Conserved Domains (1) summary
      cl15255
      Location:235 → 356
      SH2; Src homology 2 (SH2) domain

    5. XM_006506834.5 → XP_006506897.1  SH2 domain-containing protein 6 isoform X5

      See identical proteins and their annotated locations for XP_006506897.1

      UniProtKB/TrEMBL
      A0A3Q4EGG3, E0CYY5, E2QRQ0
      Related
      ENSMUSP00000123776.2, ENSMUST00000159877.3
      Conserved Domains (1) summary
      cl15255
      Location:128 → 249
      SH2; Src homology 2 (SH2) domain

    6. XM_011241549.4 → XP_011239851.1  SH2 domain-containing protein 6 isoform X4

      See identical proteins and their annotated locations for XP_011239851.1

    7. XM_036152305.1 → XP_036008198.1  SH2 domain-containing protein 6 isoform X4

    RNA

    1. XR_004933622.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D413.1 GenPept UniProtKB/Swiss-Prot:Q9D413

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools