RECK reversion inducing cysteine rich protein with kazal motifs [Homo sapiens (human)] - Gene

Summary

Official Symbol: RECKprovided by HGNC
Official Full Name: reversion inducing cysteine rich protein with kazal motifsprovided by HGNC
Primary source: HGNC:HGNC:11345
See related: Ensembl:ENSG00000122707 MIM:605227; AllianceGenome:HGNC:11345
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ST15
Summary: The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Expression: Ubiquitous expression in gall bladder (RPKM 6.7), endometrium (RPKM 6.4) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p13.3

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (36036913..36124455)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (36058906..36146459)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (36036910..36124452)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association between the Reduced Expression of RECK and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
Title: Association between the Reduced Expression of RECK and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.
Title: miR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK.
Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
Title: Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer.
[miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
Title: [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)].
RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.
Title: RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study.
Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.
Title: Mycoplasma pneumoniae downregulates RECK to promote matrix metalloproteinase-9 secretion by bronchial epithelial cells.
RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.
Title: RECK Variants are Associated with Clinicopathological Features and Decreased Susceptibility in Mexican Patients with Colorectal Cancer.
Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
Title: Methylation degree of metalloproteinase inhibitor RECK gene: Links to RECK protein level and hepatocellular carcinoma in chronic HCV infection patients.
Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.
Title: Reversion inducing cysteine rich protein with Kazal motifs and cardiovascular diseases: The RECKlessness of adverse remodeling.
MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.
Title: MiR-590-5p regulates cell proliferation, apoptosis, migration and invasion in oral squamous cell carcinoma by targeting RECK.

Submit: New GeneRIF Correction See all GeneRIFs (156)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70038 (e-PCR)
- UniSTS:66152

RH28658 (e-PCR)
- UniSTS:91558

D13S1621 (e-PCR)
- UniSTS:473550

D6S438 (e-PCR)
- UniSTS:2773

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables metalloendopeptidase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood vessel maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in embryo implantation	IEA Inferred from Electronic Annotation more info
involved_in embryonic forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of metalloendopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of establishment of blood-brain barrier	IEA Inferred from Electronic Annotation more info
involved_in regulation of extracellular matrix organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of Wnt signalosome	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: reversion-inducing cysteine-rich protein with Kazal motifs

Names: membrane-anchored glycoprotein (metastasis and invasion); suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); suppressor of tumorigenicity 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001316345.2 → NP_001303274.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains two alternate exons in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK292653, BC050306

UniProtKB/TrEMBL

A8K9D8

Conserved Domains (2) summary

pfam14828
Location:674 → 739

Amnionless

cl28910
Location:505 → 571

MFS; Major Facilitator Superfamily
NM_001316346.2 → NP_001303275.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform 3 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK292653, AL138834, BC060806, BX393623, CA431378

UniProtKB/TrEMBL

Q6P9E2
NM_001316347.2 → NP_001303276.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform 4 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK292653, BC060806, CA431378, JQ756320

UniProtKB/TrEMBL

Q6P9E2
NM_001316348.2 → NP_001303277.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform 5 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (5) uses an alternate 3'-most exon in place of the last 13 exons compared to variant 1. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK292653, BC060806, CA431378

UniProtKB/TrEMBL

Q6P9E2

Related

ENST00000479053.1
NM_021111.3 → NP_066934.1 reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor

See identical proteins and their annotated locations for NP_066934.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK292653, BC050306, D50406

Consensus CDS

CCDS6597.1

UniProtKB/Swiss-Prot

B2RNS1, O95980, Q5W0K6, Q8WX37

UniProtKB/TrEMBL

A8K9D8

Related

ENSP00000367202.3, ENST00000377966.4

Conserved Domains (2) summary

pfam03137
Location:633 → 658

OATP; Organic Anion Transporter Polypeptide (OATP) family

pfam14828
Location:802 → 886

Amnionless; Amnionless