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    LINC00491 long intergenic non-protein coding RNA 491 [ Homo sapiens (human) ]

    Gene ID: 285708, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC00491provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 491provided by HGNC
    Primary source
    HGNC:HGNC:43428
    See related
    Ensembl:ENSG00000250682 AllianceGenome:HGNC:43428
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See LINC00491 in Genome Data Viewer
    Location:
    5q21.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (102608492..102671464, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (103116594..103179563, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (101944196..102007168, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901035 Neighboring gene uncharacterized LOC124901036 Neighboring gene long intergenic non-protein coding RNA 492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:101996845-101997345 Neighboring gene VISTA enhancer hs1649 Neighboring gene uncharacterized LOC105379104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16207 Neighboring gene NANOG hESC enhancer GRCh37_chr5:102085276-102085842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:102090038-102090563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:102091571-102092071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22856 Neighboring gene peptidylglycine alpha-amidating monooxygenase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16209 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:102363594-102364793 Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer. Wang W, et al. J Transl Med, 2021 Dec 7. PMID 34876144, Free PMC Article
    2. Long non‑coding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma. Ye H, et al. Int J Mol Med, 2021 Apr. PMID 33537830, Free PMC Article
    3. Long non-coding RNAs expressed in pancreatic ductal adenocarcinoma and lncRNA BC008363 an independent prognostic factor in PDAC. Li J, et al. Pancreatology, 2014 Sep-Oct. PMID 25200694
    4. LINC00491 Facilitates Tumor Progression of Lung Adenocarcinoma via Wnt/β-Catenin-Signaling Pathway by Regulating MTSS1 Ubiquitination. Wan H, et al. Cells, 2022 Nov 23. PMID 36496997, Free PMC Article
    5. Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway. Cui D, et al. Cytokine, 2024 Mar. PMID 38150791

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway.
      Title: Long non-coding RNA LINC00491 accelerates head and neck squamous cell carcinoma progression through regulating miR-508-3p/SATB1 axis and activating Wnt signaling pathway.
    2. Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
      Title: Silencing LINC00491 inhibits prostate cancer development through the miR-384/TRIM44 axis.
    3. LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer.
      Title: LINC00491 promotes cell growth and metastasis through miR-324-5p/ROCK1 in liver cancer.
    4. Long noncoding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma.
      Title: Long non‑coding RNA LINC00491 promotes proliferation and inhibits apoptosis in esophageal squamous cell carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • CTD-2340E1.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_103753.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC099487, DA458115, DA458823
      Related
      ENST00000513815.2

    2. NR_103754.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon and contains two alternate internal exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC099487, CN270888, DA458823
      Related
      ENST00000505527.6

    3. NR_103755.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon and contains an alternate internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC099487, DA458823
      Related
      ENST00000508339.2

    4. NR_103756.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an internal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AC099487, BG777293, DA458823

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      102608492..102671464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      103116594..103179563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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