OSMR oncostatin M receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: OSMRprovided by HGNC
Official Full Name: oncostatin M receptorprovided by HGNC
Primary source: HGNC:HGNC:8507
See related: Ensembl:ENSG00000145623 MIM:601743; AllianceGenome:HGNC:8507
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OSMRB; PLCA1; IL-31RB; OSMRbeta; IL-31R-beta
Summary: This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Expression: Ubiquitous expression in gall bladder (RPKM 13.2), placenta (RPKM 11.5) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5p13.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (38846012..38945579)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (39095483..39194986)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (38846114..38935743)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease.
Title: Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease.
Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis.
Title: Oncostatin M receptor is overexpressed in oral squamous cell carcinoma and connected to poor prognosis.
Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
Title: Association of oncostatin M receptor polymorphisms with clinical recurrence of ovarian cancer in the Chinese Han population.
The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure.
Title: The Role of Oncostatin M and Its Receptor Complexes in Cardiomyocyte Protection, Regeneration, and Failure.
OSMRbeta mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients.
Title: OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients.
Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
Title: Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis.
Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
Title: Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.
Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.
Title: Oncostatin-M Does Not Predict Treatment Response in Inflammatory Bowel Disease in a Pediatric Cohort.
Whole-exome analysis of metaplastic breast carcinomas with extensive osseous differentiation.
Title: Whole-exome analysis of metaplastic breast carcinomas with extensive osseous differentiation.
The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling.
Title: The OSMR Gene Is Involved in Hirschsprung Associated Enterocolitis Susceptibility through an Altered Downstream Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (56)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Amyloidosis, primary localized cutaneous, 1 MedGen: C4551501 OMIM: 105250 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat-induced upregulation of oncostatin M receptor (OSMR) in primary human brain microvascular endothelial cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH122036 (e-PCR)
- UniSTS:134672

RH15616 (e-PCR)
- UniSTS:26652

OSMR_218 (e-PCR)
- UniSTS:277546

D5S2638 (e-PCR)
- UniSTS:20048

D10S16 (e-PCR)
- UniSTS:155756

GDB:314481 (e-PCR)
- UniSTS:79850

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to oncostatin-M receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to oncostatin-M receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in oncostatin-M-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of acute inflammatory response	IC Inferred by Curator more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of oncostatin-M receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: oncostatin-M-specific receptor subunit beta

Names: IL-31 receptor subunit beta; IL-31R subunit beta; interleukin-31 receptor subunit beta; oncostatin-M specific receptor beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016236.2 RefSeqGene

Range

5002..94631

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001168355.3 → NP_001161827.1 oncostatin-M-specific receptor subunit beta isoform 2 precursor

See identical proteins and their annotated locations for NP_001161827.1

Status: REVIEWED

Source sequence(s)

BC010943, BM893608

Consensus CDS

CCDS54847.1

UniProtKB/Swiss-Prot

Q99650

Related

ENSP00000422023.1, ENST00000502536.5

Conserved Domains (1) summary

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001323504.2 → NP_001310433.1 oncostatin-M-specific receptor subunit beta isoform 2 precursor

Status: REVIEWED

Source sequence(s)

BC010943, BM893608, DR006275

Consensus CDS

CCDS54847.1

UniProtKB/Swiss-Prot

Q99650

Conserved Domains (1) summary

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001323505.2 → NP_001310434.1 oncostatin-M-specific receptor subunit beta isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AC026713, AI417125, BU619548, CA439576, CB265977, U60805

Consensus CDS

CCDS3928.1

UniProtKB/Swiss-Prot

Q6P4E8, Q96QJ6, Q99650

Conserved Domains (3) summary

cd00063
Location:625 → 733

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:539 → 607

fn3; Fibronectin type III domain

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001323506.2 → NP_001310435.1 oncostatin-M-specific receptor subunit beta isoform 3 precursor

Status: REVIEWED

Source sequence(s)

AC026713, AI417125, BU619548, CA439576, CB265977, U60805

UniProtKB/Swiss-Prot

Q99650

Conserved Domains (4) summary

smart00060
Location:335 → 407

FN3; Fibronectin type 3 domain

cd00063
Location:626 → 734

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:540 → 608

fn3; Fibronectin type III domain

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001323507.2 → NP_001310436.1 oncostatin-M-specific receptor subunit beta isoform 4 precursor

Status: REVIEWED

Source sequence(s)

AI417125, BQ772952, U60805

UniProtKB/Swiss-Prot

Q99650

Conserved Domains (2) summary

cd00063
Location:335 → 419

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:30 → 138

LIFR_D2; Leukemia inhibitory factor receptor D2 domain
NM_003999.3 → NP_003990.1 oncostatin-M-specific receptor subunit beta isoform 1 precursor

See identical proteins and their annotated locations for NP_003990.1

Status: REVIEWED

Source sequence(s)

BP352496, BU619548, CA439576, CB265977, DR006275, U60805

Consensus CDS

CCDS3928.1

UniProtKB/Swiss-Prot

Q6P4E8, Q96QJ6, Q99650

Related

ENSP00000274276.3, ENST00000274276.8

Conserved Domains (3) summary

cd00063
Location:625 → 733

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:539 → 607

fn3; Fibronectin type III domain

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

38846012..38945579

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514161.3 → XP_011512463.1 oncostatin-M-specific receptor subunit beta isoform X3

Conserved Domains (4) summary

smart00060
Location:335 → 407

FN3; Fibronectin type 3 domain

cd00063
Location:626 → 734

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:540 → 608

fn3; Fibronectin type III domain

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_017010019.2 → XP_016865508.1 oncostatin-M-specific receptor subunit beta isoform X4
XM_047417872.1 → XP_047273828.1 oncostatin-M-specific receptor subunit beta isoform X4
XM_005248384.1 → XP_005248441.1 oncostatin-M-specific receptor subunit beta isoform X1

See identical proteins and their annotated locations for XP_005248441.1

Conserved Domains (4) summary

smart00060
Location:335 → 407

FN3; Fibronectin type 3 domain

cd00063
Location:626 → 734

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:540 → 608

fn3; Fibronectin type III domain

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_005248386.3 → XP_005248443.1 oncostatin-M-specific receptor subunit beta isoform X5

Conserved Domains (3) summary

smart00060
Location:335 → 407

FN3; Fibronectin type 3 domain

cd00063
Location:446 → 522

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:233 → 288

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_005248387.3 → XP_005248444.1 oncostatin-M-specific receptor subunit beta isoform X6

Conserved Domains (2) summary

cd00063
Location:335 → 419

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam17971
Location:30 → 138

LIFR_D2; Leukemia inhibitory factor receptor D2 domain
XM_047417873.1 → XP_047273829.1 oncostatin-M-specific receptor subunit beta isoform X5
XM_047417870.1 → XP_047273826.1 oncostatin-M-specific receptor subunit beta isoform X1
XM_047417871.1 → XP_047273827.1 oncostatin-M-specific receptor subunit beta isoform X2

UniProtKB/Swiss-Prot

Q6P4E8, Q96QJ6, Q99650

RNA

XR_925661.1 RNA Sequence
XR_007058659.1 RNA Sequence
XR_007058660.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

39095483..39194986

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353784.1 → XP_054209759.1 oncostatin-M-specific receptor subunit beta isoform X3
XM_054353785.1 → XP_054209760.1 oncostatin-M-specific receptor subunit beta isoform X4
XM_054353786.1 → XP_054209761.1 oncostatin-M-specific receptor subunit beta isoform X4
XM_054353781.1 → XP_054209756.1 oncostatin-M-specific receptor subunit beta isoform X1
XM_054353787.1 → XP_054209762.1 oncostatin-M-specific receptor subunit beta isoform X5
XM_054353789.1 → XP_054209764.1 oncostatin-M-specific receptor subunit beta isoform X6
XM_054353788.1 → XP_054209763.1 oncostatin-M-specific receptor subunit beta isoform X5
XM_054353782.1 → XP_054209757.1 oncostatin-M-specific receptor subunit beta isoform X1
XM_054353783.1 → XP_054209758.1 oncostatin-M-specific receptor subunit beta isoform X2

UniProtKB/Swiss-Prot

Q6P4E8, Q96QJ6, Q99650