NOTUM notum, palmitoleoyl-protein carboxylesterase [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOTUMprovided by HGNC
Official Full Name: notum, palmitoleoyl-protein carboxylesteraseprovided by HGNC
Primary source: HGNC:HGNC:27106
See related: Ensembl:ENSG00000185269 MIM:609847; AllianceGenome:HGNC:27106
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hNOTUM
Summary: Enables palmitoleyl hydrolase activity. Involved in negative regulation of Wnt signaling pathway and protein depalmitoleylation. Acts upstream of or within bone development and regulation of bone mineralization. Predicted to be located in endoplasmic reticulum lumen and extracellular region. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward placenta (RPKM 82.6) See more
Orthologs: mouse all
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Genomic context

Location:: 17q25.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (81952507..81961187, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (82819665..82828345, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (79910383..79919063, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway.
Title: Notum enhances gastric cancer stem-like cell properties through upregulation of Sox2 by PI3K/AKT signaling pathway.
NOTUM plays a bidirectionally modulatory role in the odontoblastic differentiation of human stem cells from the apical papilla through the WNT/beta-catenin signaling pathway.
Title: NOTUM plays a bidirectionally modulatory role in the odontoblastic differentiation of human stem cells from the apical papilla through the WNT/β-catenin signaling pathway.
Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/beta-catenin signaling via p-GSK3beta.
Title: Notum leads to potential pro-survival of OSCC through crosstalk between Shh and Wnt/β-catenin signaling via p-GSK3β.
Notum deacylates octanoylated ghrelin.
Title: Notum deacylates octanoylated ghrelin.
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
Title: Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma.
NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Title: NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.
Title: Structural characterization of melatonin as an inhibitor of the Wnt deacylase Notum.
Therapies targeting osteoblast-derived NOTUM may prevent nonvertebral fractures.
Title: Osteoblast-derived NOTUM reduces cortical bone mass in mice and the NOTUM locus is associated with bone mineral density in humans.
results reveal a role of the stem cell niche in ageing and demonstrate that targeting of Notum can promote regeneration of aged tissues
Title: Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium.
NOTUM expression was increased in metastatic cells. Proliferation was suppressed by inhibiting expression of NOTUM. Knockdown of NOTUM genes inhibited proliferation as well as migration, with possible involvement of p38 and c-JUN N-terminal kinase in this process.
Title: NOTUM Is Involved in the Progression of Colorectal Cancer.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC33854 (e-PCR)
- UniSTS:79994

SHGC-83062 (e-PCR)
- UniSTS:101299

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables palmitoleyl hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoleyl hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase C activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein depalmitoleylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: palmitoleoyl-protein carboxylesterase NOTUM

Names: [Wnt protein] O-palmitoleoyl-L-serine hydrolase; notum pectinacetylesterase homolog; protein notum homolog

NP_848588.3

EC 3.1.1.98

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.