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    fli-1 Protein flightless-1 homolog [ Caenorhabditis elegans ]

    Gene ID: 176215, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fli-1
    Official Full Name
    Protein flightless-1 homolog
    Primary source
    WormBase:WBGene00001443
    Locus tag
    CELE_B0523.5
    See related
    AllianceGenome:WB:WBGene00001443
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin cytoskeleton organization; actin filament severing; and barbed-end actin filament capping. Located in nucleus. Is expressed in body wall musculature; germ line; hermaphrodite gonad; and non-striated muscle. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human FLII (FLII actin remodeling protein). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fli-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (8675297..8683736, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene C-mannosyltransferase dpy-19 Neighboring gene Uncharacterized protein Neighboring gene P granule abnormality protein 2 Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene tRNA-Trp Neighboring gene Nicotinamide N-methyltransferase Neighboring gene putative 3-ketoacyl-CoA thiolase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel Ras-binding protein Ce-FLI-1 comprising leucine-rich repeats and gelsolin-like domains. Goshima M, et al. Biochem Biophys Res Commun, 1999 Apr 2. PMID 10092519
    2. FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans. Lu J, et al. BMC Dev Biol, 2008 May 16. PMID 18485202, Free PMC Article
    3. The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Deng H, et al. Genetics, 2007 Oct. PMID 17720906, Free PMC Article
    4. The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans. Campbell HD, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248259, Free PMC Article
    5. Architecture of the cortical actomyosin network driving apical constriction in C. elegans. Zhang P, et al. J Cell Biol, 2023 Sep 4. PMID 37351566, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FLI-1 controls germ line morphogenesis and rachis organization
      Title: FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans.
    2. fli-1 plays an important role in regulating the actin-dependent events during C. elegans development.
      Title: The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Protein flightless-1 homolog
    NP_498913.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8675297..8683736 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066512.6 → NP_498913.2  Protein flightless-1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498913.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34268, P90739, Q17331
      Conserved Domains (9) summary
      cd11280
      Location:629 → 717
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:1034 → 1141
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:502 → 613
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:738 → 837
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd00116
      Location:129 → 373
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:341 → 363
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:105 → 128
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:245 → 303
      LRR_8; Leucine rich repeat
      cl15697
      Location:1151 → 1250
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34268.2

    Gene LinkOut

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