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    gly-5 Polypeptide N-acetylgalactosaminyltransferase 5 [ Caenorhabditis elegans ]

    Gene ID: 176736, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gly-5
    Official Full Name
    Polypeptide N-acetylgalactosaminyltransferase 5
    Primary source
    WormBase:WBGene00001630
    Locus tag
    CELE_Y39E4B.12
    See related
    AllianceGenome:WB:WBGene00001630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables polypeptide N-acetylgalactosaminyltransferase activity. Involved in protein O-linked glycosylation via threonine. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POC1B-GALNT4 (POC1B-GALNT4 readthrough); GALNT12 (polypeptide N-acetylgalactosaminyltransferase 12); and GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See gly-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    13
    Sequence:
    Chromosome: III; NC_003281.10 (13187390..13204897)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SNAPc (Small Nuclear RNA Activating Complex) homolog Neighboring gene ncRNA Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene UDG domain-containing protein Neighboring gene Tetraspanin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA cloning and expression of a family of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase sequence homologs from Caenorhabditis elegans. Hagen FK, et al. J Biol Chem, 1998 Apr 3. PMID 9525933
    2. The terminal phase of cytokinesis in the Caenorhabditis elegans early embryo requires protein glycosylation. Wang H, et al. Mol Biol Cell, 2005 Sep. PMID 15987734, Free PMC Article
    3. Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. Schwientek T, et al. J Biol Chem, 2002 Jun 21. PMID 11925450
    4. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables polypeptide N-acetylgalactosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in protein O-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein O-linked glycosylation via threonine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Polypeptide N-acetylgalactosaminyltransferase 5
    NP_001022852.1
    • Confirmed by transcript evidence
    NP_001370120.1
    • Confirmed by transcript evidence
    NP_001379253.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13187390..13204897
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001027681.9 → NP_001022852.1  Polypeptide N-acetylgalactosaminyltransferase 5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95ZJ1
      Conserved Domains (4) summary
      cd02510
      Location:178 → 477
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:173 → 448
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:490 → 607
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:488 → 605
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    2. NM_001383020.1 → NP_001370120.1  Polypeptide N-acetylgalactosaminyltransferase 5 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (2) summary
      cd02510
      Location:178 → 477
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:488 → 604
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    3. NM_001392225.1 → NP_001379253.1  Polypeptide N-acetylgalactosaminyltransferase 5 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O61391, O61392, O61393, Q95ZJ1, Q95ZJ2, Q9U2J8
      Conserved Domains (2) summary
      cd02510
      Location:178 → 477
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      pfam00652
      Location:488 → 607
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95ZJ1.2

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