U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dnj-25 J domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180356, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dnj-25
    Official Full Name
    J domain-containing protein
    Primary source
    WormBase:WBGene00001043
    Locus tag
    CELE_W07A8.3
    See related
    AllianceGenome:WB:WBGene00001043
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Is expressed in hypodermis and pharynx. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 19A. Orthologous to several human genes including DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dnj-25 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    17
    Sequence:
    Chromosome: V; NC_003283.11 (20729948..20744346, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene F-box C protein Neighboring gene Phospholipase A(2);phospholipase A2 Neighboring gene F-box associated domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene pseudo Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Defective pharyngeal development protein 4 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Caenorhabditis elegans auxilin: a J-domain protein essential for clathrin-mediated endocytosis in vivo. Greener T, et al. Nat Cell Biol, 2001 Feb. PMID 11175756
    2. Increased gene dosage and mRNA expression from chromosomal duplications in Caenorhabditis elegans. Ragipani B, et al. G3 (Bethesda), 2022 Jul 29. PMID 35731207, Free PMC Article
    3. GAK and PRKCD are positive regulators of PRKN-independent mitophagy. Munson MJ, et al. Nat Commun, 2021 Oct 20. PMID 34671015, Free PMC Article
    4. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Curran SP, et al. Nature, 2009 Jun 25. PMID 19506556, Free PMC Article
    5. Intracellular trafficking. Grant BD, et al. WormBook, 2006 Jan 21. PMID 18050485, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables clathrin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in clathrin coat disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin-dependent endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    J domain-containing protein
    NP_001256947.1
    • Confirmed by transcript evidence
    NP_001256948.1
    • Confirmed by transcript evidence
    NP_001256949.1
    • Confirmed by transcript evidence
    NP_001360578.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      20729948..20744346 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373209.3 → NP_001360578.1  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXP9
      Conserved Domains (2) summary
      smart00271
      Location:735 → 782
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:466 → 660
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. NM_001270020.4 → NP_001256949.1  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFQ6
      Conserved Domains (2) summary
      smart00271
      Location:390 → 437
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:123 → 315
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    3. NM_001270018.3 → NP_001256947.1  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDJ6
      Conserved Domains (2) summary
      smart00271
      Location:733 → 780
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:466 → 658
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    4. NM_001270019.3 → NP_001256948.1  J domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      D7SFQ5
      Conserved Domains (2) summary
      smart00271
      Location:407 → 454
      DnaJ; DnaJ molecular chaperone homology domain
      pfam05109
      Location:140 → 332
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools