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    cyp-31A2 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 178065, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyp-31A2
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00010354
    Locus tag
    CELE_H02I12.8
    See related
    AllianceGenome:WB:WBGene00010354
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in several processes, including asymmetric cell division; eggshell formation; and polar body extrusion after meiotic divisions. Used to study Bietti crystalline corneoretinal dystrophy. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyp-31A2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    6
    Sequence:
    Chromosome: IV; NC_003282.8 (11403961..11406091)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Histone H2A Neighboring gene ncRNA Neighboring gene MEiosis-to-MItosis transition associated Neighboring gene Histone H3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo. Benenati G, et al. Mech Dev, 2009 May-Jun. PMID 19368796
    2. Xenobiotic detoxification in the nematode Caenorhabditis elegans. Lindblom TH, et al. J Exp Zool A Comp Exp Biol, 2006 Sep 1. PMID 16902959, Free PMC Article
    3. Oocyte signals derived from polyunsaturated fatty acids control sperm recruitment in vivo. Kubagawa HM, et al. Nat Cell Biol, 2006 Oct. PMID 16998478
    4. Changes in Nuclear Receptor and Vitellogenin Gene Expression in Response to Steroids and Heavy Metal in Caenorhabditis elegans. Novillo A, et al. Integr Comp Biol, 2005 Jan. PMID 21676746
    5. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of both cyp-31A2 and cyp-31A3 either by RNAi or using a double deletion mutant, led to the failure of establishing the correct polarity of the embryo and to complete the extrusion of the polar bodies during meiosis.
      Title: Two cytochrome P450s in Caenorhabditis elegans are essential for the organization of eggshell, correct execution of meiosis and the polarization of embryo.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in asymmetric cell division IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in eggshell formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryonic morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CYtochrome P450 family
    NP_502152.3
    • Product from WormBase gene class cyp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11403961..11406091
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069751.7 → NP_502152.3  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502152.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGT6
      Conserved Domains (1) summary
      pfam00067
      Location:36 → 472
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

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