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    cra-1 N-terminal acetyltransferase B complex subunit NAA25 homolog [ Caenorhabditis elegans ]

    Gene ID: 175956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cra-1
    Official Full Name
    N-terminal acetyltransferase B complex subunit NAA25 homolog
    Primary source
    WormBase:WBGene00020068
    Locus tag
    CELE_R13F6.10
    See related
    AllianceGenome:WB:WBGene00020068
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acetyltransferase activator activity. Predicted to be involved in cytoskeleton organization. Predicted to be located in chromosome and nucleus. Predicted to be part of NatB complex. Predicted to be active in cytoplasm. Is expressed in body wall musculature; intestine; and reproductive system. Orthologous to human NAA25 (N-alpha-acetyltransferase 25, NatB auxiliary subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cra-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    20
    Sequence:
    Chromosome: III; NC_003281.10 (6865206..6869460, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Dwarfin sma-3 Neighboring gene KNL (kinetochore null) Binding Protein Neighboring gene Uncharacterized protein Neighboring gene Nucleoporin;Nucleoporin NUP35

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. N-terminal acetylation promotes synaptonemal complex assembly in C. elegans. Gao J, et al. Genes Dev, 2016 Nov 1. PMID 27881602, Free PMC Article
    2. Leptotene/zygotene chromosome movement via the SUN/KASH protein bridge in Caenorhabditis elegans. Baudrimont A, et al. PLoS Genet, 2010 Nov 24. PMID 21124819, Free PMC Article
    3. CRA-1 uncovers a double-strand break-dependent pathway promoting the assembly of central region proteins on chromosome axes during C. elegans meiosis. Smolikov S, et al. PLoS Genet, 2008 Jun 6. PMID 18535664, Free PMC Article
    4. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. Gao J, et al. PLoS Genet, 2015 Mar. PMID 25768301, Free PMC Article
    5. Identification and characterization of novel nicotinic receptor-associated proteins in Caenorhabditis elegans. Gottschalk A, et al. EMBO J, 2005 Jul 20. PMID 15990870, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acetyltransferase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of NatB complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-terminal acetyltransferase B complex subunit NAA25 homolog
    NP_498494.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6865206..6869460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066093.7 → NP_498494.2  N-terminal acetyltransferase B complex subunit NAA25 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498494.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21986
      Conserved Domains (3) summary
      sd00006
      Location:42 → 71
      TPR; TPR repeat [structural motif]
      pfam09797
      Location:261 → 641
      NatB_MDM20; N-acetyltransferase B complex (NatB) non catalytic subunit
      pfam14559
      Location:20 → 83
      TPR_19; Tetratricopeptide repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21986.3

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