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    ile-1 L-type lectin-like domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172799, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ile-1
    Official Full Name
    L-type lectin-like domain-containing protein
    Primary source
    WormBase:WBGene00002070
    Locus tag
    CELE_K07A1.8
    See related
    AllianceGenome:WB:WBGene00002070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable D-mannose binding activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi membrane; and endoplasmic reticulum-Golgi intermediate compartment. Human ortholog(s) of this gene implicated in factor V deficiency and factor XIII deficiency. Orthologous to several human genes including LMAN1 (lectin, mannose binding 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ile-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (9609544..9611534, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene Aquaporin Neighboring gene Sm domain-containing protein Neighboring gene ATE_N domain-containing protein;Arginyl-tRNA--protein transferase 1 Neighboring gene Large ribosomal subunit protein mL64

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Berends CW, et al. Mol Biol Cell, 2013 Jul. PMID 23699393, Free PMC Article
    2. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article
    3. Robust co-immunoprecipitation with mass spectrometry for Caenorhabditis elegans using solid-phase enhanced sample preparation. Baytek G, et al. Biotechniques, 2022 May. PMID 35297663
    4. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
    5. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in IRE1-mediated unfolded protein response HEP PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-type lectin-like domain-containing protein
    NP_492548.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9609544..9611534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060147.7 → NP_492548.1  L-type lectin-like domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492548.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EDE8
      Conserved Domains (2) summary
      cd06902
      Location:26 → 250
      lectin_ERGIC-53_ERGL; ERGIC-53 and ERGL type 1 transmembrane proteins, N-terminal lectin domain
      pfam06785
      Location:250 → 346
      UPF0242; Uncharacterized protein family (UPF0242)
    Nucleotide Protein
    Heading Accession and Version

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