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    sago-1 Piwi-like protein [ Caenorhabditis elegans ]

    Gene ID: 179016, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sago-1
    Official Full Name
    Piwi-like protein
    Primary source
    WormBase:WBGene00019666
    Locus tag
    CELE_K12B6.1
    See related
    AllianceGenome:WB:WBGene00019666
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA endonuclease activity; miRNA binding activity; and single-stranded RNA binding activity. Predicted to be involved in regulatory ncRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Predicted to be active in cytoplasmic ribonucleoprotein granule and nucleus. Is expressed in several structures, including hypodermis; intestine; nervous system; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See sago-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    15
    Sequence:
    Chromosome: V; NC_003283.11 (6303771..6308337)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Activin_recp domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint. Gu SG, et al. Nat Genet, 2012 Jan 8. PMID 22231482, Free PMC Article
    2. New Strains for Tissue-Specific RNAi Studies in Caenorhabditis elegans. Watts JS, et al. G3 (Bethesda), 2020 Nov 5. PMID 32943454, Free PMC Article
    3. A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions. Seroussi U, et al. Elife, 2023 Feb 15. PMID 36790166, Free PMC Article
    4. Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Yigit E, et al. Cell, 2006 Nov 17. PMID 17110334
    5. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Grishok A, et al. Cell, 2001 Jul 13. PMID 11461699

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Piwi-like protein
    NP_504610.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      6303771..6308337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072209.5 → NP_504610.1  Piwi-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0T7CIX3
      Conserved Domains (2) summary
      smart00949
      Location:281 → 412
      PAZ; This domain is named PAZ after the proteins Piwi Argonaut and Zwille
      cd02826
      Location:443 → 844
      Piwi-like; Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The ...
    Nucleotide Protein
    Heading Accession and Version

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