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    nprt-1 Nicotinate phosphoribosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 177070, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nprt-1
    Official Full Name
    Nicotinate phosphoribosyltransferase
    Primary source
    WormBase:WBGene00021882
    Locus tag
    CELE_Y54G2A.17
    See related
    AllianceGenome:WB:WBGene00021882
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable nicotinate phosphoribosyltransferase activity. Predicted to be involved in NAD salvage and response to oxidative stress. Predicted to be active in cytosol. Is expressed in intestine; nervous system; and reproductive system. Orthologous to human NAPRT (nicotinate phosphoribosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nprt-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    8
    Sequence:
    Chromosome: IV; NC_003282.8 (2872023..2890451, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BLVR domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene Inner membrane protein;Transmembrane protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Endoplasmic reticulum transmembrane protein Neighboring gene Thioredoxin-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LAB-1 targets PP1 and restricts Aurora B kinase upon entrance into meiosis to promote sister chromatid cohesion. Tzur YB, et al. PLoS Biol, 2012. PMID 22927794, Free PMC Article
    2. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    3. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinate phosphoribosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NAD salvage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Nicotinate phosphoribosyltransferase
    NP_001368085.1
    • Confirmed by transcript evidence
    NP_001380099.1
    • Confirmed by transcript evidence
    NP_500265.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2872023..2890451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001392274.1 → NP_001380099.1  Nicotinate phosphoribosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21457
      Location:5 → 541
      TIM; TIM-like beta/alpha barrel domains

    2. NM_067864.6 → NP_500265.3  Nicotinate phosphoribosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500265.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WTL1, Q95XX1
      Conserved Domains (2) summary
      PLN02885
      Location:25 → 561
      PLN02885; nicotinate phosphoribosyltransferase
      cd01570
      Location:30 → 415
      NAPRTase_A; Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction ...

    3. NM_001380118.1 → NP_001368085.1  Nicotinate phosphoribosyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cl21457
      Location:5 → 221
      TIM; TIM-like beta/alpha barrel domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XX1.3

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