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    nsun-4 5-methylcytosine rRNA methyltransferase nsun-4 [ Caenorhabditis elegans ]

    Gene ID: 171790, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nsun-4
    Official Full Name
    5-methylcytosine rRNA methyltransferase nsun-4
    Primary source
    WormBase:WBGene00021476
    Locus tag
    CELE_Y39G10AR.21
    See related
    AllianceGenome:WB:WBGene00021476
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables rRNA (cytosine-C5-)-methyltransferase activity and tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in rRNA methylation and tRNA processing. Predicted to be located in mitochondrion. Orthologous to human NSUN4 (NOP2/Sun RNA methyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nsun-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (2308976..2312129)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Inner centromere protein ARK-binding domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene Tubulin-specific chaperone A Neighboring gene protein-synthesizing GTPase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. Heissenberger C, et al. Elife, 2020 Dec 8. PMID 33289480, Free PMC Article
    2. Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans. Navarro IC, et al. EMBO J, 2021 Mar 15. PMID 33283887, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA (cytidine-5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    5-methylcytosine rRNA methyltransferase nsun-4
    NP_001293364.1
    • Confirmed by transcript evidence
    NP_001293365.1
    • Confirmed by transcript evidence
    NP_490958.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      2308976..2312129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058557.4 → NP_490958.1  5-methylcytosine rRNA methyltransferase nsun-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95XR2, X5LQ37, X5LVB3
      Conserved Domains (1) summary
      COG0144
      Location:234 → 394
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    2. NM_001306435.3 → NP_001293364.1  5-methylcytosine rRNA methyltransferase nsun-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LVB3
      Conserved Domains (1) summary
      COG0144
      Location:145 → 305
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    3. NM_001306436.3 → NP_001293365.1  5-methylcytosine rRNA methyltransferase nsun-4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293365.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LQ37
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XR2.1

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