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    ccm-3 Programmed cell death protein 10 homolog [ Caenorhabditis elegans ]

    Gene ID: 174638, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ccm-3
    Official Full Name
    Programmed cell death protein 10 homolog
    Primary source
    WormBase:WBGene00007561
    Locus tag
    CELE_C14A4.11
    See related
    AllianceGenome:WB:WBGene00007561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein kinase binding activity. Involved in several processes, including positive regulation of GTPase activity; positive regulation of endocytic recycling; and regulation of Golgi organization. Located in cytoplasm; cytoplasmic side of apical plasma membrane; and growing cell tip. Is expressed in several structures, including excretory cell; head; intestine; pharynx; and reproductive system. Used to study cerebral cavernous malformation. Human ortholog(s) of this gene implicated in cerebral cavernous malformation 3. Orthologous to human PDCD10 (programmed cell death 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ccm-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (10605717..10607275, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C6 domain-containing protein Neighboring gene Serpentine receptor class gamma Neighboring gene Transcription initiation factor TFIID subunit 13 Neighboring gene Phosphatidylinositol-glycan biosynthesis class W protein Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Generation and Analysis of CCM Phenotypes in C. elegans. Popiel E, et al. Methods Mol Biol, 2020. PMID 32524554
    2. Interrogating the ccm-3 Gene Network. Lant B, et al. Cell Rep, 2018 Sep 11. PMID 30208312
    3. Novel cytokinetic ring components drive negative feedback in cortical contractility. Bell KR, et al. Mol Biol Cell, 2020 Jul 15. PMID 32491957, Free PMC Article
    4. CentTracker: a trainable, machine-learning-based tool for large-scale analyses of Caenorhabditis elegans germline stem cell mitosis. Zellag RM, et al. Mol Biol Cell, 2021 Apr 19. PMID 33502892, Free PMC Article
    5. The initial expansion of the C. elegans syncytial germ line is coupled to incomplete primordial germ cell cytokinesis. Bauer J, et al. Development, 2021 Sep 15. PMID 34195824, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study establishes CCM-3 as a novel regulator of rachis lumenization and polarity establishment during embryogenesis.
      Title: CCM-3 Promotes C. elegans Germline Development by Regulating Vesicle Trafficking Cytokinesis and Polarity.
    2. GCK-1 works together with CCM-3, a known binding partner, to promote intercellular bridge stability and limit localization of both canonical anillin and non-muscle myosin II (NMM-II) to intercellular bridges
      Title: A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges.
    3. CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
      Title: CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi reassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial tube morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of FAR/SIN/STRIPAK complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in growing cell tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Programmed cell death protein 10 homolog
    NP_496290.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10605717..10607275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063889.8 → NP_496290.2  Programmed cell death protein 10 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496290.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17958
      Conserved Domains (1) summary
      pfam06840
      Location:5 → 161
      DUF1241; Protein of unknown function (DUF1241)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17958.2

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