kin-3 Casein kinase II subunit alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kin-3
Official Full Name: Casein kinase II subunit alpha
Primary source: WormBase:WBGene00002191
Locus tag: CELE_B0205.7
See related: AllianceGenome:WB:WBGene00002191
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation; response to hermaphrodite contact; and vulval location. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Part of protein kinase CK2 complex. Is expressed in oocyte. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1) and CSNK2A3 (casein kinase 2 alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See kin-3 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 8

Sequence:: Chromosome: I; NC_003279.8 (10734022..10736615)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that DEAD-box RNA helicase, CGH-1/DDX6, as a key casein kinase II (CK2) substrate and phosphorylation of a conserved N-terminal serine is required for CGH-1 function in the microRNA (miRNA) pathway.
Title: Casein kinase II promotes target silencing by miRISC through direct phosphorylation of the DEAD-box RNA helicase CGH-1.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0205.7 (e-PCR)
- UniSTS:313360

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to hermaphrodite contact	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Casein kinase II subunit alpha

NP_492811.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

10734022..10736615

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_060410.5 → NP_492811.1 Casein kinase II subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_492811.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P18334

Conserved Domains (2) summary

cd14132
Location:19 → 323

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

pfam00069
Location:38 → 323

Pkinase; Protein kinase domain