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    dhs-4 DeHydrogenases, Short chain [ Caenorhabditis elegans ]

    Gene ID: 172810, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhs-4
    Official Full Name
    DeHydrogenases, Short chain
    Primary source
    WormBase:WBGene00000968
    Locus tag
    CELE_T05F1.10
    See related
    AllianceGenome:WB:WBGene00000968
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be active in lipid droplet. Orthologous to human SDR16C5 (short chain dehydrogenase/reductase family 16C member 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhs-4 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9647603..9649238, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phosphate carrier protein, mitochondrial Neighboring gene Uncharacterized protein Neighboring gene F-box associated domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene protein-disulfide reductase Neighboring gene Long arms of the bivalent protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydroxysteroid dehydrogenase family proteins on lipid droplets through bacteria, C. elegans, and mammals. Liu Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2018 Aug. PMID 29702244
    2. Systematic temperature signaling regulates behavior plasticity. Li Y. Protein Cell, 2011 Oct. PMID 22058030, Free PMC Article
    3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
    4. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DeHydrogenases, Short chain
    NP_492563.1
    • Product from WormBase gene class dhs;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9647603..9649238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060162.4 → NP_492563.1  DeHydrogenases, Short chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O18030
      Conserved Domains (2) summary
      cd05339
      Location:43 → 286
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      pfam00106
      Location:41 → 235
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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