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    abf-2 Antibacterial factor-related peptide 2 [ Caenorhabditis elegans ]

    Gene ID: 266826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    abf-2
    Official Full Name
    Antibacterial factor-related peptide 2
    Primary source
    WormBase:WBGene00000013
    Locus tag
    CELE_C50F2.10
    See related
    AllianceGenome:WB:WBGene00000013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Predicted to be located in extracellular region. Is expressed in excretory cell; marginal cell; and pharyngeal neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See abf-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003279.8 (3885631..3885888, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ubiquitin-like modifier-activating enzyme 5 Neighboring gene Protein SYS1 homolog Neighboring gene Pre-mRNA-splicing factor SYF1 Neighboring gene CCHC-type domain-containing protein Neighboring gene Antibacterial factor-related peptide 1 Neighboring gene DUF281 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Overexpression of an antimicrobial peptide derived from C. elegans using an aggregation-prone protein coexpression system. Tomisawa S, et al. AMB Express, 2013 Aug 15. PMID 23945047, Free PMC Article
    2. Identification of virulence properties in Salmonella Typhimurium DT104 using Caenorhabditis elegans. Sahu SN, et al. PLoS One, 2013. PMID 24124587, Free PMC Article
    3. abf-1 and abf-2, ASABF-type antimicrobial peptide genes in Caenorhabditis elegans. Kato Y, et al. Biochem J, 2002 Jan 15. PMID 11772394, Free PMC Article
    4. Resistance to antimicrobial peptides contributes to persistence of Salmonella typhimurium in the C. elegans intestine. Alegado RA, et al. Cell Microbiol, 2008 Jun. PMID 18221392
    5. Assessment of nanopolystyrene toxicity under fungal infection condition in Caenorhabditis elegans. Li D, et al. Ecotoxicol Environ Saf, 2020 Jul 1. PMID 32302863

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to other organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Antibacterial factor-related peptide 2
    NP_491252.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3885631..3885888 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058851.6 → NP_491252.1  Antibacterial factor-related peptide 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491252.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EC68, Q9NL69
      Conserved Domains (1) summary
      pfam16839
      Location:24 → 77
      Antimicrobial25; Nematode antimicrobial peptide
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EC68.1

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