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    clc-2 Clc-like protein 2 [ Caenorhabditis elegans ]

    Gene ID: 180999, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clc-2
    Official Full Name
    Clc-like protein 2
    Primary source
    WormBase:WBGene00000523
    Locus tag
    CELE_C01C10.1
    See related
    AllianceGenome:WB:WBGene00000523
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in epithelial cell-cell adhesion. Located in plasma membrane. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clc-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (7431465..7433535)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Clc-like protein 5 Neighboring gene MYM-type domain-containing protein Neighboring gene Putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The voltage-gated anion channels encoded by clh-3 regulate egg laying in C. elegans by modulating motor neuron excitability. Branicky R, et al. J Neurosci, 2014 Jan 15. PMID 24431435, Free PMC Article
    2. Identification and characterization of a new member of the gas3/PMP22 gene family in C. elegans. Agostoni E, et al. Gene, 1999 Jul 8. PMID 10395899
    3. Double the keys, double the control: coupled phosphorylation sites provide novel molecular targets for precise control of ion channel function. Focus on "Differential regulation of a CLC anion channel by SPAK kinase ortholog-mediated multisite phosphorylation". Duan DD, et al. Am J Physiol Cell Physiol, 2012 Jun 15. PMID 22496246, Free PMC Article
    4. Claudins in Caenorhabditis elegans: their distribution and barrier function in the epithelium. Asano A, et al. Curr Biol, 2003 Jun 17. PMID 12814550
    5. Claudin family proteins in Caenorhabditis elegans. Simske JS, et al. Methods Mol Biol, 2011. PMID 21717355

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell-cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Clc-like protein 2
    NP_001362078.1
    • Confirmed by transcript evidence
    NP_509257.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7431465..7433535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001375068.3 → NP_001362078.1  Clc-like protein 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IK28
      Conserved Domains (1) summary
      pfam07062
      Location:3 → 153
      Clc-like

    2. NM_076856.7 → NP_509257.1  Clc-like protein 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509257.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q11085, Q9NGJ8
      Conserved Domains (1) summary
      pfam07062
      Location:3 → 200
      Clc-like; Clc-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11085.2

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