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    mab-20 Semaphorin-2A [ Caenorhabditis elegans ]

    Gene ID: 171727, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mab-20
    Official Full Name
    Semaphorin-2A
    Primary source
    WormBase:WBGene00003111
    Locus tag
    CELE_Y71G12B.20
    See related
    AllianceGenome:WB:WBGene00003111
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables semaphorin receptor binding activity. Involved in several processes, including axon development; embryonic morphogenesis; and male anatomical structure morphogenesis. Located in cell surface. Is expressed in several structures, including linker cell; ray neurons; ray precursor cell; somatic nervous system; and vulval cell. Orthologous to human SEMA3B (semaphorin 3B) and SEMA3C (semaphorin 3C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mab-20 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (1644588..1651457, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Coiled-coil domain-containing protein Neighboring gene Mucin-5AC Neighboring gene Methyltransferase FkbM domain-containing protein Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis in C. elegans. Ginzburg VE, et al. Development, 2002 May. PMID 11959817
    2. Semaphorin and Eph receptor signaling guide a series of cell movements for ventral enclosure in C. elegans. Ikegami R, et al. Curr Biol, 2012 Jan 10. PMID 22197242, Free PMC Article
    3. Semaphorin signaling restricts neuronal regeneration in C. elegans. Harreguy MB, et al. Front Cell Dev Biol, 2022. PMID 36325362, Free PMC Article
    4. mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans. Roy PJ, et al. Development, 2000 Feb. PMID 10648234
    5. The divergent C. elegans ephrin EFN-4 functions inembryonic morphogenesis in a pathway independent of the VAB-1 Eph receptor. Chin-Sang ID, et al. Development, 2002 Dec. PMID 12403719

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EFN-4 and PLX-2 are coexpressed in the late embryonic epidermis where they play redundant roles in MAB-20-dependent cell sorting.
      Title: The PLEXIN PLX-2 and the ephrin EFN-4 have distinct roles in MAB-20/Semaphorin 2A signaling in Caenorhabditis elegans morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chemorepellent activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables semaphorin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of embryonic epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nematode male tail mating organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in semaphorin-plexin signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Semaphorin-2A
    NP_001293443.1
    • Confirmed by transcript evidence
    NP_001293444.1
    • Confirmed by transcript evidence
    NP_490875.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1644588..1651457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058474.5 → NP_490875.1  Semaphorin-2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490875.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q86LT8, Q95XP4, Q9NI38, W6RTP3, W6SBL1
      Conserved Domains (3) summary
      smart00408
      Location:556 → 596
      IGc2; Immunoglobulin C-2 Type
      cd11238
      Location:34 → 477
      Sema_2A; The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A)
      pfam01437
      Location:478 → 521
      PSI; Plexin repeat

    2. NM_001306514.3 → NP_001293443.1  Semaphorin-2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293443.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RTP3
      Conserved Domains (3) summary
      pfam01437
      Location:358 → 401
      PSI; Plexin repeat
      cl11960
      Location:435 → 472
      Ig; Immunoglobulin domain
      cl15693
      Location:1 → 357
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    3. NM_001306515.3 → NP_001293444.1  Semaphorin-2A [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293444.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBL1
      Conserved Domains (3) summary
      pfam01437
      Location:301 → 344
      PSI; Plexin repeat
      cl11960
      Location:378 → 415
      Ig; Immunoglobulin domain
      cl15693
      Location:1 → 300
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    RNA

    1. NR_165326.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95XP4.1

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