dpyd-1 Dihydropyrimidine dehydrogenase [NADP(+)] [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpyd-1
Official Full Name: Dihydropyrimidine dehydrogenase [NADP(+)]
Primary source: WormBase:WBGene00016103
Locus tag: CELE_C25F6.3
See related: AllianceGenome:WB:WBGene00016103
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and pancreatic cancer. Orthologous to human DPYD (dihydropyrimidine dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dpyd-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (5467870..5472683)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-140 (e-PCR)
- UniSTS:242520

C25F6.3 (e-PCR)
- UniSTS:308633

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IBA Inferred from Biological aspect of Ancestor more info
enables dihydropyrimidine dehydrogenase (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables dihydropyrimidine dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables dihydropyrimidine dehydrogenase (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
enables uracil binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in beta-alanine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in thymidine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in thymine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in uracil catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in uracil catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Dihydropyrimidine dehydrogenase [NADP(+)]

NP_508927.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5467870..5472683

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076526.7 → NP_508927.2 Dihydropyrimidine dehydrogenase [NADP(+)] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508927.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18164

Conserved Domains (6) summary

PRK08318
Location:546 → 1019

PRK08318; dihydropyrimidine dehydrogenase subunit B; Validated

PRK11749
Location:69 → 523

PRK11749; dihydropyrimidine dehydrogenase subunit A; Provisional

cd02940
Location:546 → 848

DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...

pfam13187
Location:964 → 1009

Fer4_9; 4Fe-4S dicluster domain

pfam13450
Location:206 → 251

NAD_binding_8; NAD(P)-binding Rossmann-like domain

pfam14691
Location:71 → 183

Fer4_20; Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster