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    met-2 Histone-lysine N-methyltransferase met-2 [ Caenorhabditis elegans ]

    Gene ID: 176183, updated on 9-Dec-2024

    Summary

    Official Symbol
    met-2
    Official Full Name
    Histone-lysine N-methyltransferase met-2
    Primary source
    WormBase:WBGene00019883
    Locus tag
    CELE_R05D3.11
    See related
    AllianceGenome:WB:WBGene00019883
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables histone H3K36 methyltransferase activity and histone H3K9 methyltransferase activity. Involved in several processes, including negative regulation of vulval development; regulation of gene expression; and vulval cell fate commitment. Located in cytoplasm. Is expressed in several structures, including germ line; hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to several human genes including SETDB1 (SET domain bifurcated histone lysine methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See met-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (8375300..8380848)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene LIMR family protein R05D3.2 Neighboring gene DNA topoisomerase 2;Putative DNA topoisomerase 2, mitochondrial Neighboring gene Uncharacterized protein

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3K36 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K9 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K9me2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-lysine N-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heterochromatin organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of vulval development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sex differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vulval cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Histone-lysine N-methyltransferase met-2
    NP_498848.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8375300..8380848
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066447.7NP_498848.4  Histone-lysine N-methyltransferase met-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498848.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34544, Q8WTP5
      Conserved Domains (3) summary
      smart00468
      Location:9211035
      PreSET; N-terminal to some SET domains
      smart00317
      Location:10521278
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd01395
      Location:839902
      HMT_MBD; Methyl-CpG binding domains (MBD) present in putative histone methyltransferases (HMT) such as CLLD8 and SETDB1 proteins; CLLD8 contains a MBD, a PreSET and a bifurcated SET domain, suggesting that CLLD8 might be associated with methylation-mediated ...