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    • Showing Current items.

    npp-22 Nucleoporin ndc-1 [ Caenorhabditis elegans ]

    Gene ID: 179607, updated on 9-Dec-2024

    Summary

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    Official Symbol
    npp-22
    Official Full Name
    Nucleoporin ndc-1
    Primary source
    WormBase:WBGene00007118
    Locus tag
    CELE_B0240.4
    See related
    AllianceGenome:WB:WBGene00007118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in nuclear pore organization. Part of nuclear pore. Orthologous to human NDC1 (NDC1 transmembrane nucleoporin). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See npp-22 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (11731120..11733472, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Receptor-type guanylate cyclase daf-11;guanylate cyclase Neighboring gene Ammonium transporter AmtB-like domain-containing protein Neighboring gene Dendritic cell-specific transmembrane protein-like domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. Stavru F, et al. J Cell Biol, 2006 May 22. PMID 16702233, Free PMC Article
    2. The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. Mansfeld J, et al. Mol Cell, 2006 Apr 7. PMID 16600873
    3. A broad requirement for TLS polymerases η and κ, and interacting sumoylation and nuclear pore proteins, in lesion bypass during C. elegans embryogenesis. Roerink SF, et al. PLoS Genet, 2012 Jun. PMID 22761594, Free PMC Article
    4. Analysis of Nuclear Pore Complexes in Caenorhabditis elegans by Live Imaging and Functional Genomics. de la Cruz Ruiz P, et al. Methods Mol Biol, 2022. PMID 35412238
    5. Nucleoporin foci are stress-sensitive condensates dispensable for C. elegans nuclear pore assembly. Thomas L, et al. EMBO J, 2023 Jul 3. PMID 37254647, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore transmembrane ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nucleoporin ndc-1
    NP_505962.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11731120..11733472 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073561.8 → NP_505962.2  Nucleoporin ndc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505962.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8I4N3
      Conserved Domains (1) summary
      pfam09531
      Location:77 → 577
      Ndc1_Nup; Nucleoporin protein Ndc1-Nup
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I4N3.1

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