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    rgs-5 RGS domain-containing protein;Regulator of G-protein signaling rgs-5 [ Caenorhabditis elegans ]

    Gene ID: 175794, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rgs-5
    Official Full Name
    RGS domain-containing protein;Regulator of G-protein signaling rgs-5
    Primary source
    WormBase:WBGene00004348
    Locus tag
    CELE_B0336.4
    See related
    AllianceGenome:WB:WBGene00004348
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein localization. Predicted to be active in mitochondrion and plasma membrane. Is expressed in nervous system. Orthologous to human AKAP10 (A-kinase anchoring protein 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rgs-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (5698555..5702305)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Transcription initiation factor IIA small chain homolog Neighboring gene THAP-type domain-containing protein Neighboring gene Ubiquitin-like protein atg-12 Neighboring gene Protein SWAP;SURP motif domain-containing protein;Suppressor of white apricot N-terminal domain-containing protein Neighboring gene Large ribosomal subunit protein uL14 Neighboring gene Major sperm protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple RGS proteins alter neural G protein signaling to allow C. elegans to rapidly change behavior when fed. Dong MQ, et al. Genes Dev, 2000 Aug 15. PMID 10950865, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RGS domain-containing protein;Regulator of G-protein signaling rgs-5
    NP_001122672.1
    • Confirmed by transcript evidence
    NP_498229.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5698555..5702305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129200.4 → NP_001122672.1  RGS domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122672.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A9Z1K0
      Conserved Domains (2) summary
      pfam00615
      Location:181 → 303
      RGS; Regulator of G protein signaling domain
      cl02565
      Location:81 → 170
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. NM_065828.9 → NP_498229.3  Regulator of G-protein signaling rgs-5 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498229.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10955
      Conserved Domains (2) summary
      smart00315
      Location:214 → 336
      RGS; Regulator of G protein signalling domain
      pfam00615
      Location:81 → 203
      RGS; Regulator of G protein signaling domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10955.4

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