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    unc-96 CRE-UNC-96 protein [ Caenorhabditis elegans ]

    Gene ID: 180413, updated on 9-Dec-2024

    Summary

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    Official Symbol
    unc-96
    Official Full Name
    CRE-UNC-96 protein
    Primary source
    WormBase:WBGene00006825
    Locus tag
    CELE_F13C5.6
    See related
    AllianceGenome:WB:WBGene00006825
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables myosin binding activity. Involved in locomotion; regulation of cytoskeleton organization; and striated muscle myosin thick filament assembly. Located in M band and striated muscle myosin thick filament. Is expressed in anal depressor muscle; body wall musculature; and pharyngeal muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See unc-96 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (611120..621290, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene EB domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans UNC-96 is a new component of M-lines that interacts with UNC-98 and paramyosin and is required in adult muscle for assembly and/or maintenance of thick filaments. Mercer KB, et al. Mol Biol Cell, 2006 Sep. PMID 16790495, Free PMC Article
    2. UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans. Miller RK, et al. Mol Biol Cell, 2008 Apr. PMID 18256289, Free PMC Article
    3. Sequences in the myosin A rod interact with UNC-89/obscurin and the zinc-finger protein UNC-98 during thick filament assembly and M-line formation in C. elegans striated muscle. Almuhanna SA, et al. Cytoskeleton (Hoboken), 2024 Dec. PMID 38400829
    4. The Role of the UNC-82 Protein Kinase in Organizing Myosin Filaments in Striated Muscle of Caenorhabditis elegans. Schiller NR, et al. Genetics, 2017 Mar. PMID 28040740, Free PMC Article
    5. CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle. Miller RK, et al. Mol Biol Cell, 2009 Aug. PMID 19535455, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that CSN-5 functions in muscle cells to regulate UNC-98 and -96, two M-line proteins.
      Title: CSN-5, a component of the COP9 signalosome complex, regulates the levels of UNC-96 and UNC-98, two components of M-lines in Caenorhabditis elegans muscle.
    2. model in which UNC-98 and -96 may act as chaperones to promote the incorporation of paramyosin into thick filaments
      Title: UNC-98 and UNC-96 interact with paramyosin to promote its incorporation into thick filaments of Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cytoskeletal protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in locomotion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in striated muscle myosin thick filament assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in striated muscle myosin thick filament assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in striated muscle myosin thick filament IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CRE-UNC-96 protein
    NP_741703.1
    • Confirmed by transcript evidence
    NP_741704.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      611120..621290 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171612.8 → NP_741703.1  CRE-UNC-96 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76566

    2. NM_171939.5 → NP_741704.1  CRE-UNC-96 protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZR3
    Nucleotide Protein
    Heading Accession and Version

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