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    eme-1 Crossover junction endonuclease MUS81;ERCC4 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eme-1
    Official Full Name
    Crossover junction endonuclease MUS81;ERCC4 domain-containing protein
    Primary source
    WormBase:WBGene00018923
    Locus tag
    CELE_F56A6.4
    See related
    AllianceGenome:WB:WBGene00018923
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Predicted to be involved in double-strand break repair via break-induced replication; mitotic intra-S DNA damage checkpoint signaling; and resolution of meiotic recombination intermediates. Predicted to be part of Holliday junction resolvase complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See eme-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    8
    Sequence:
    Chromosome: I; NC_003279.8 (614651..629444, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Unconventional myosin-IXa-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Piwi domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene RNA helicase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interplay between structure-specific endonucleases for crossover control during Caenorhabditis elegans meiosis. Saito TT, et al. PLoS Genet, 2013. PMID 23874210, Free PMC Article
    2. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to crossover junction DNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via break-induced replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic intra-S DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Crossover junction endonuclease MUS81;ERCC4 domain-containing protein
    NP_001293209.1
    • Confirmed by transcript evidence
    NP_001293210.1
    • Confirmed by transcript evidence
    NP_001293211.1
    • Confirmed by transcript evidence
    NP_490757.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      614651..629444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058356.4 → NP_490757.3  ERCC4 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490757.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GZG5
      Conserved Domains (1) summary
      pfam08496
      Location:98 → 148
      Peptidase_S49_N; Peptidase family S49 N-terminal

    2. NM_001306281.3 → NP_001293210.1  ERCC4 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLH9
      Conserved Domains (1) summary
      PTZ00121
      Location:33 → 105
      PTZ00121; MAEBL; Provisional

    3. NM_001306282.3 → NP_001293211.1  Crossover junction endonuclease MUS81 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293211.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJ54

    4. NM_001306280.3 → NP_001293209.1  Crossover junction endonuclease MUS81 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLM3
    Nucleotide Protein
    Heading Accession and Version

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