rrp-8 Ribosomal RNA-processing protein 8 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rrp-8
Official Full Name: Ribosomal RNA-processing protein 8
Primary source: WormBase:WBGene00020296
Locus tag: CELE_T07A9.8
See related: AllianceGenome:WB:WBGene00020296
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable methylated histone binding activity. Predicted to be involved in cellular response to glucose starvation; rDNA heterochromatin formation; and regulation of transcription by glucose. Predicted to be located in rDNA heterochromatin. Predicted to be part of chromatin silencing complex. Predicted to be active in nucleolus. Is expressed widely. Orthologous to human RRP8 (ribosomal RNA processing 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See rrp-8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 5

Sequence:: Chromosome: IV; NC_003282.8 (396545..399095)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07A9.8 (e-PCR)
- UniSTS:319615

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables methylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rDNA heterochromatin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by glucose	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin silencing complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin silencing complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in rDNA heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in rDNA heterochromatin	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Ribosomal RNA-processing protein 8

NP_499920.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

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Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

396545..399095

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067519.5 → NP_499920.1 Ribosomal RNA-processing protein 8 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_499920.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44410

Conserved Domains (1) summary

pfam05148
Location:130 → 343

Methyltransf_8; Hypothetical methyltransferase