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    nkcc-1 Solute carrier family 12 member 1 [ Caenorhabditis elegans ]

    Gene ID: 3565648, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nkcc-1
    Official Full Name
    Solute carrier family 12 member 1
    Primary source
    WormBase:WBGene00012543
    Locus tag
    CELE_Y37A1C.1
    See related
    AllianceGenome:WB:WBGene00012543
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sodium:potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Is expressed in body wall musculature; intestine; neurons; oocyte; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 78; essential hypertension; middle cerebral artery infarction; and renal tubular transport disease (multiple). Orthologous to several human genes including SLC12A1 (solute carrier family 12 member 1) and SLC12A2 (solute carrier family 12 member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nkcc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (14107720..14124056, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene INSulin related Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An evolutionarily conserved switch in response to GABA affects development and behavior of the locomotor circuit of Caenorhabditis elegans. Han B, et al. Genetics, 2015 Apr. PMID 25644702, Free PMC Article
    2. Metolazone upregulates mitochondrial chaperones and extends lifespan in Caenorhabditis elegans. Ito A, et al. Biogerontology, 2021 Feb. PMID 33216250
    3. Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans. Shanley HT, et al. Bioorg Med Chem, 2024 Jan 15. PMID 38134663
    4. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Ji W, et al. Nat Genet, 2008 May. PMID 18391953, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride:monoatomic cation symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium:potassium:chloride symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Solute carrier family 12 member 1
    NP_001076724.1
    • Confirmed by transcript evidence
    NP_001255788.1
    • Confirmed by transcript evidence
    NP_001255789.1
    • Confirmed by transcript evidence
    NP_001255790.1
    • Partially confirmed by transcript evidence
    NP_001255791.1
    • Confirmed by transcript evidence
    NP_001263812.1
    • Confirmed by transcript evidence
    NP_502704.1
    • Partially confirmed by transcript evidence
    NP_502705.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      14107720..14124056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001268862.4 → NP_001255791.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255791.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESD4
      Conserved Domains (3) summary
      TIGR00930
      Location:141 → 1186
      2a30; K-Cl cotransporter
      pfam03522
      Location:727 → 1186
      SLC12; Solute carrier family 12
      cl00456
      Location:299 → 662
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_001276883.3 → NP_001263812.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263812.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E912
      Conserved Domains (3) summary
      TIGR00930
      Location:143 → 1188
      2a30; K-Cl cotransporter
      pfam03522
      Location:729 → 1188
      SLC12; Solute carrier family 12
      cl00456
      Location:301 → 664
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_001268861.4 → NP_001255790.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESD5
      Conserved Domains (3) summary
      TIGR00930
      Location:165 → 1235
      2a30; K-Cl cotransporter
      pfam03522
      Location:751 → 1235
      SLC12; Solute carrier family 12
      cl00456
      Location:323 → 686
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001083255.4 → NP_001076724.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EEQ4
      Conserved Domains (3) summary
      TIGR00930
      Location:165 → 1210
      2a30; K-Cl cotransporter
      pfam03522
      Location:751 → 1210
      SLC12; Solute carrier family 12
      cl00456
      Location:323 → 686
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_001268859.3 → NP_001255788.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255788.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P897
      Conserved Domains (2) summary
      TIGR00930
      Location:1 → 870
      2a30; K-Cl cotransporter
      pfam03522
      Location:411 → 870
      SLC12; Solute carrier family 12

    6. NM_001268860.3 → NP_001255789.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001255789.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E9P898
      Conserved Domains (1) summary
      pfam03522
      Location:89 → 548
      SLC12; Solute carrier family 12

    7. NM_070303.2 → NP_502704.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFE5
      Conserved Domains (3) summary
      pfam00324
      Location:249 → 742
      AA_permease; Amino acid permease
      pfam03522
      Location:751 → 886
      SLC12; Solute carrier family 12
      cl00456
      Location:323 → 686
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    8. NM_070304.1 → NP_502705.1  Solute carrier family 12 member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFN5
    Nucleotide Protein
    Heading Accession and Version

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