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    ragc-1 Ras-related GTP-binding protein C [ Caenorhabditis elegans ]

    Gene ID: 178084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ragc-1
    Official Full Name
    Ras-related GTP-binding protein C
    Primary source
    WormBase:WBGene00012497
    Locus tag
    CELE_Y24F12A.2
    See related
    AllianceGenome:WB:WBGene00012497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Involved in determination of adult lifespan and regulation of autophagosome assembly. Predicted to be located in membrane. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Is expressed in intestine. Human ortholog(s) of this gene implicated in renal hypomagnesemia 7, with or without dilated cardiomyopathy. Orthologous to human RRAGC (Ras related GTP binding C) and RRAGD (Ras related GTP binding D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ragc-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (11603613..11604933, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Abnormal cell migration protein 38 Neighboring gene Small ribosomal subunit protein uS17 Neighboring gene Deoxyribonuclease TATDN2 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. Murphy JT, et al. PLoS Biol, 2019 May. PMID 31086360, Free PMC Article
    2. Nutritional control of postembryonic development progression and arrest in Caenorhabditis elegans. Mata-Cabana A, et al. Adv Genet, 2021. PMID 33641748
    3. mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation. Zhang G, et al. Cell, 2018 Sep 6. PMID 30173914
    4. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Robida-Stubbs S, et al. Cell Metab, 2012 May 2. PMID 22560223, Free PMC Article
    5. Surviving starvation simply without TFEB. Soukas AA, et al. PLoS Biol, 2019 May. PMID 31136567, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Gtr1-Gtr2 GTPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related GTP-binding protein C
    NP_001293887.1
    • Confirmed by transcript evidence
    NP_502187.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      11603613..11604933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069786.6 → NP_502187.1  Ras-related GTP-binding protein C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502187.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EGB3
      Conserved Domains (1) summary
      cd11385
      Location:28 → 201
      RagC_like; Rag GTPase, subfamily of Ras-related GTPases, includes Ras-related GTP-binding proteins C and D

    2. NM_001306958.3 → NP_001293887.1  Ras-related GTP-binding protein C [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A061ACG4
    Nucleotide Protein
    Heading Accession and Version

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