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    tim-1 Protein timeless homolog [ Caenorhabditis elegans ]

    Gene ID: 176652, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tim-1
    Official Full Name
    Protein timeless homolog
    Primary source
    WormBase:WBGene00006571
    Locus tag
    CELE_Y75B8A.22
    See related
    AllianceGenome:WB:WBGene00006571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity. Involved in embryo development; regulation of sister chromatid cohesion; and sister chromatid cohesion. Located in nucleus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and alcohol use disorder. Orthologous to human TIMELESS (timeless circadian regulator). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tim-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (12240367..12250164, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RING-type E3 ubiquitin transferase Neighboring gene Ground-like domain-containing protein Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes. Banerjee D, et al. Dev Cell, 2005 Feb. PMID 15691769
    2. Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins. Jeon M, et al. Science, 1999 Nov 5. PMID 10550049
    3. TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans. Xia Y, et al. EMBO J, 2021 Sep 1. PMID 34269473, Free PMC Article
    4. Chromosome cohesion is regulated by a clock gene paralogue TIM-1. Chan RC, et al. Nature, 2003 Jun 26. PMID 12827206
    5. Getting (chromosomes) loaded--a new role for timeless. Golden A, et al. Dev Cell, 2003 Jul. PMID 12852847

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans.
      Title: TIMELESS-TIPIN and UBXN-3 promote replisome disassembly during DNA replication termination in Caenorhabditis elegans.
    2. tim-1 and kin-20, the C. elegans homologs of the Drosophila circadian clock genes timeless and doubletime, respectively, are required to maintain late-larval identity and prevent premature expression of adult cell fates.
      Title: Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.
    3. participation in the regulation of chromosome cohesion
      Title: Chromosome cohesion is regulated by a clock gene paralogue TIM-1.
    4. tim-1 has a role in sister chromatid cohesion.
      Title: Getting (chromosomes) loaded--a new role for timeless.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sister chromatid cohesion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork arrest IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of replication fork protection complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein timeless homolog
    NP_499594.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      12240367..12250164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067193.8 → NP_499594.2  Protein timeless homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499594.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EDN3
      Conserved Domains (2) summary
      pfam05029
      Location:874 → 1099
      TIMELESS_C; Timeless protein C terminal region
      pfam04821
      Location:20 → 277
      TIMELESS; Timeless protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EDN3.1

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