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    kca-1 Kinesin Cargo Adaptor [ Caenorhabditis elegans ]

    Gene ID: 172090, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kca-1
    Official Full Name
    Kinesin Cargo Adaptor
    Primary source
    WormBase:WBGene00015698
    Locus tag
    CELE_C10H11.10
    See related
    AllianceGenome:WB:WBGene00015698
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables kinesin binding activity. Involved in embryo development; establishment of meiotic spindle localization; and polar body extrusion after meiotic divisions. Part of kinesin I complex. Is expressed in gonad and oocyte. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kca-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (4759820..4761321, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene HP domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Protein kinase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Centriole engagement: it's not just cohesin any more. Sluder G. Curr Biol, 2013 Aug 5. PMID 23928085
    2. Kinesin-dependent transport results in polarized migration of the nucleus in oocytes and inward movement of yolk granules in meiotic embryos. McNally KL, et al. Dev Biol, 2010 Mar 1. PMID 20036653, Free PMC Article
    3. Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans. Ellefson ML, et al. Mol Biol Cell, 2009 Jun. PMID 19357192, Free PMC Article
    4. Asymmetric division: a kinesin for spindle positioning. McCarthy EK, et al. Curr Biol, 2005 Aug 9. PMID 16085478
    5. Kinesin-1 mediates translocation of the meiotic spindle to the oocyte cortex through KCA-1, a novel cargo adapter. Yang HY, et al. J Cell Biol, 2005 May 9. PMID 15883196, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables kinesin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of meiotic spindle localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polar body extrusion after meiotic divisions IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of kinesin I complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Kinesin Cargo Adaptor
    NP_491443.3
    • Product from WormBase gene class kca;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      4759820..4761321 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059042.6 → NP_491443.3  Kinesin Cargo Adaptor [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491443.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBU5
    Nucleotide Protein
    Heading Accession and Version

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