Y37E11B.5 tRNA-dihydrouridine(47) synthase [NAD(P)(+)] [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y37E11B.5
Official Full Name: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]
Primary source: WormBase:WBGene00021377
Locus tag: CELE_Y37E11B.5
See related: AllianceGenome:WB:WBGene00021377
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable tRNA dihydrouridine synthase activity. Predicted to be involved in tRNA dihydrouridine synthesis. Is expressed in body wall musculature; intestine; nervous system; pharynx; and reproductive system. Orthologous to human DUS3L (dihydrouridine synthase 3 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See Y37E11B.5 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (3593954..3598552, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y37E11B.7 (e-PCR)
- UniSTS:316179

Y37E11B.5 (e-PCR)
- UniSTS:313298

Y37E11B.6 (e-PCR)
- UniSTS:320765

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dihydrouridine synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA dihydrouridine synthesis	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]

NP_500379.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

3593954..3598552 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_067978.5 → NP_500379.1 tRNA-dihydrouridine(47) synthase [NAD(P)(+)] [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_500379.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9TYN2

Conserved Domains (2) summary

COG0042
Location:196 → 481

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd02801
Location:205 → 443

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...