icd-2 Nascent polypeptide-associated complex subunit alpha [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: icd-2
Official Full Name: Nascent polypeptide-associated complex subunit alpha
Primary source: WormBase:WBGene00022042
Locus tag: CELE_Y65B4BR.5
See related: AllianceGenome:WB:WBGene00022042
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Is expressed in intestinal cell and muscle cell. Orthologous to several human genes including NACA4P (NACA family member 4, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See icd-2 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (535791..536587)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y65B4B_10.b (e-PCR)
- UniSTS:323216

Y65B4B_10.c (e-PCR)
- UniSTS:323217

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nascent polypeptide-associated complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Nascent polypeptide-associated complex subunit alpha

NP_490749.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

535791..536587

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058348.6 → NP_490749.1 Nascent polypeptide-associated complex subunit alpha [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490749.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q86S66, Q9N2Z8

Conserved Domains (2) summary

cd14358
Location:158 → 194

UBA_NAC_euk; UBA-like domain found in nascent polypeptide-associated complex subunit alpha (NACA) and its homologs mainly found in eukaryotes

cd22054
Location:70 → 117

NAC_NACA; nascent polypeptide-associated complex (NAC), alpha subunit