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    cdt-1 CDT1 Geminin-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 171896, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cdt-1
    Official Full Name
    CDT1 Geminin-binding domain-containing protein
    Primary source
    WormBase:WBGene00000413
    Locus tag
    CELE_Y54E10A.15
    See related
    AllianceGenome:WB:WBGene00000413
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA binding activity and DNA polymerase binding activity. Involved in positive regulation of nematode male tail tip morphogenesis. Located in chromatin; cytoplasm; and nucleus. Is expressed in anchor cell; germ line; uterine epithelial cell; and vulD. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 4. Orthologous to human CDT1 (chromatin licensing and DNA replication factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cdt-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (3223160..3228104, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene rhomboid protease Neighboring gene Thioredoxin-like protein Neighboring gene Conserved oligomeric Golgi complex subunit 1 Neighboring gene Male abnormal protein mab-31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA-replication licensing. Zhong W, et al. Nature, 2003 Jun 19. PMID 12815436
    2. C. elegans CUL-4 prevents rereplication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Kim J, et al. Curr Biol, 2007 Jun 5. PMID 17509881, Free PMC Article
    3. The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex. Kim Y, et al. Mol Cell Biol, 2007 Feb. PMID 17145765, Free PMC Article
    4. The dynamics of replication licensing in live Caenorhabditis elegans embryos. Sonneville R, et al. J Cell Biol, 2012 Jan 23. PMID 22249291, Free PMC Article
    5. Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. Yanagi K, et al. J Biol Chem, 2005 May 20. PMID 15811859

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication
      Title: CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
    2. Caenorhabditis elegans DDB-1 is required for the degradation of CDT-1 during S phase. DDB-1 interacts specifically with CUL-4 but not with other C. elegans cullins.
      Title: The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication preinitiation complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated DNA replication initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CDT1 Geminin-binding domain-containing protein
    NP_001040707.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      3223160..3228104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047242.4 → NP_001040707.1  CDT1 Geminin-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040707.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86S68
      Conserved Domains (2) summary
      cd08767
      Location:520 → 645
      Cdt1_c; The C-terminal fold of replication licensing factor Cdt1 is essential for Cdt1 activity and directly interacts with MCM2-7 helicase
      pfam08839
      Location:255 → 457
      CDT1; DNA replication factor CDT1 like
    Nucleotide Protein
    Heading Accession and Version

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