gop-1 Protein CLEC16A homolog [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: gop-1
Official Full Name: Protein CLEC16A homolog
Primary source: WormBase:WBGene00001660
Locus tag: CELE_C34E10.3
See related: AllianceGenome:WB:WBGene00001660
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in endosomal transport; regulation of autophagosome maturation; and vacuolar transport. Predicted to be active in Golgi apparatus. Predicted to colocalize with late endosome. Is expressed in coelomocyte; intestinal cell; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in Addison's disease; multiple sclerosis; rheumatoid arthritis; and type 1 diabetes mellitus. Orthologous to human CLEC16A (C-type lectin domain containing 16A). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See gop-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 16

Sequence:: Chromosome: III; NC_003281.10 (5254438..5258886)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gop-1 as a novel regulator of apoptotic cell clearance in Caenorhabditis elegans via activation of Rab2.
Title: GOP-1 promotes apoptotic cell degradation by activating the small GTPase Rab2 in C. elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

C34E10.8 (e-PCR)
- UniSTS:308713

C34E10.3 (e-PCR)
- UniSTS:309245

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in endosomal transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info
involved_in vacuolar transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with late endosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Protein CLEC16A homolog

NP_498117.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5254438..5258886

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065716.7 → NP_498117.3 Protein CLEC16A homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498117.3

Status: REVIEWED

UniProtKB/Swiss-Prot

P46578

UniProtKB/TrEMBL

Q95UF8

Conserved Domains (1) summary

pfam09758
Location:48 → 193

FPL; uncharacterized conserved protein