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    • Showing Current items.

    bre-3 Beta-1,4-mannosyltransferase bre-3 [ Caenorhabditis elegans ]

    Gene ID: 176332, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bre-3
    Official Full Name
    Beta-1,4-mannosyltransferase bre-3
    Primary source
    WormBase:WBGene00000268
    Locus tag
    CELE_B0464.4
    See related
    AllianceGenome:WB:WBGene00000268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable beta-1,4-mannosyltransferase activity. Involved in carbohydrate biosynthetic process and response to toxic substance. Located in cytoplasm. Is expressed in neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See bre-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (9469900..9485451, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Barrier-to-autointegration factor 1 Neighboring gene Neuropeptide-like peptide 36 Neighboring gene Aspartate--tRNA ligase, cytoplasmic Neighboring gene RNA polymerase-associated protein CTR9 Neighboring gene Extracellular superoxide dismutase [Cu-Zn];Superoxide dismutase [Cu-Zn]

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nematotoxicity of Marasmius oreades agglutinin (MOA) depends on glycolipid binding and cysteine protease activity. Wohlschlager T, et al. J Biol Chem, 2011 Sep 2. PMID 21757752, Free PMC Article
    2. Resistance to Bacillus thuringiensis toxin in Caenorhabditis elegans from loss of fucose. Barrows BD, et al. J Biol Chem, 2007 Feb 2. PMID 17135259
    3. Bacillus thuringiensis (Bt) toxin susceptibility and isolation of resistance mutants in the nematode Caenorhabditis elegans. Marroquin LD, et al. Genetics, 2000 Aug. PMID 10924467, Free PMC Article
    4. Resistance to a bacterial toxin is mediated by removal of a conserved glycosylation pathway required for toxin-host interactions. Griffitts JS, et al. J Biol Chem, 2003 Nov 14. PMID 12944392
    5. Use of RNAi as a preliminary tool for screening putative receptors of nematicidal toxins from Bacillus thuringiensis. García-Montelongo M, et al. Arch Microbiol, 2021 May. PMID 33432376

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables beta-1,4-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-1,4-mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycosphingolipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Beta-1,4-mannosyltransferase bre-3
    NP_499087.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9469900..9485451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066686.8 → NP_499087.2  Beta-1,4-mannosyltransferase bre-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499087.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03562
      Conserved Domains (2) summary
      COG1215
      Location:154 → 453
      BcsA; Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]
      pfam13632
      Location:184 → 382
      Glyco_trans_2_3; Glycosyl transferase family group 2

    RNA

    1. NR_132454.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03562.2

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