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    ins-5 Putative insulin-like peptide beta-type 6 [ Caenorhabditis elegans ]

    Gene ID: 191686, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ins-5
    Official Full Name
    Putative insulin-like peptide beta-type 6
    Primary source
    WormBase:WBGene00002088
    Locus tag
    CELE_ZK84.3
    See related
    AllianceGenome:WB:WBGene00002088
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hormone activity. Involved in dauer larval development. Predicted to be located in extracellular region. Is expressed in several structures, including coelomocyte; head muscle; neurons; somatic nervous system; and vulva. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ins-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (5997557..5999022)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene putative insulin-like peptide beta-type 3 Neighboring gene putative insulin-like peptide beta-type 1 Neighboring gene putative insulin-like peptide beta-type 5 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling. Segref A, et al. Nat Commun, 2022 Oct 5. PMID 36198694, Free PMC Article
    2. Ins-4 and daf-28 function redundantly to regulate C. elegans L1 arrest. Chen Y, et al. Dev Biol, 2014 Oct 15. PMID 25128585
    3. Interaction between the ins/IGF-1 and p38 MAPK signaling pathways in molecular compensation of sod genes and modulation related to intracellular ROS levels in C. elegans. Yanase S, et al. Biochem Biophys Rep, 2020 Sep. PMID 32875124, Free PMC Article
    4. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. Hung WL, et al. EMBO J, 2013 Jun 12. PMID 23665919, Free PMC Article
    5. Transcriptional profile of aging in C. elegans. Lund J, et al. Curr Biol, 2002 Sep 17. PMID 12372248

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dauer larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Putative insulin-like peptide beta-type 6
    NP_001380038.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5997557..5999022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393089.1 → NP_001380038.1  Putative insulin-like peptide beta-type 6 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P56173
      Conserved Domains (1) summary
      pfam03488
      Location:51 → 98
      Ins_beta; Nematode insulin-related peptide beta type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56173.2

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