gro-1 C2H2-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gro-1
Official Full Name: C2H2-type domain-containing protein
Primary source: WormBase:WBGene00001740
Locus tag: CELE_ZC395.6
See related: AllianceGenome:WB:WBGene00001740
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable tRNA dimethylallyltransferase activity. Involved in determination of adult lifespan and regulation of growth. Located in mitochondrion and nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See gro-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 9

Sequence:: Chromosome: III; NC_003281.10 (5265113..5267204)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prolonged life span of Clk mutants cannot be attributed to reduced metabolic rate or an increased activity of the major antioxidant enzymes catalase and SOD.
Title: No reduction of energy metabolism in Clk mutants.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC395.6 (e-PCR)
- UniSTS:306241

ZC395.7 (e-PCR)
- UniSTS:317763

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables tRNA dimethylallyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA dimethylallyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dimethylallyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity, transferring alkyl or aryl (other than methyl) groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA modification	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: C2H2-type domain-containing protein

NP_498122.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5265113..5267204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_065721.8 → NP_498122.2 C2H2-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_498122.2

Status: REVIEWED

UniProtKB/TrEMBL

G5EBS1

Conserved Domains (1) summary

COG0324
Location:16 → 319

MiaA; tRNA A37 N6-isopentenylltransferase MiaA [Translation, ribosomal structure and biogenesis]