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    cysl-4 Cysteine synthase [ Caenorhabditis elegans ]

    Gene ID: 186587, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cysl-4
    Official Full Name
    Cysteine synthase
    Primary source
    WormBase:WBGene00019096
    Locus tag
    CELE_F59A7.9
    See related
    AllianceGenome:WB:WBGene00019096
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine synthase activity. Predicted to be involved in cysteine biosynthetic process from serine. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cysl-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (2004959..2006805)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aldehyde dehydrogenase Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemical properties of nematode O-acetylserine(thiol)lyase paralogs imply their distinct roles in hydrogen sulfide homeostasis. Vozdek R, et al. Biochim Biophys Acta, 2013 Dec. PMID 24100226
    2. The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide. Budde MW, et al. Genetics, 2011 Oct. PMID 21840852, Free PMC Article
    3. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteine biosynthetic process from serine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cysteine synthase
    NP_503547.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      2004959..2006805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071146.2 → NP_503547.1  Cysteine synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503547.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O16284
      Conserved Domains (2) summary
      cd01561
      Location:15 → 305
      CBS_like; CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine. ...
      PLN02565
      Location:9 → 319
      PLN02565; cysteine synthase
    Nucleotide Protein
    Heading Accession and Version

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