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    act-5 Actin [ Caenorhabditis elegans ]

    Gene ID: 176793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    act-5
    Official Full Name
    Actin
    Primary source
    WormBase:WBGene00000067
    Locus tag
    CELE_T25C8.2
    See related
    AllianceGenome:WB:WBGene00000067
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable hydrolase activity. Involved in several processes, including larval feeding behavior; microvillus assembly; and positive regulation of eating behavior. Located in microvillar actin bundle and terminal web. Is expressed in excretory cell; gonad; intestine; pharyngeal-intestinal valve; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See act-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (13604412..13606066, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene pseudo Neighboring gene Carbohydrate kinase FGGY N-terminal domain-containing protein Neighboring gene STI1 domain-containing protein Neighboring gene Protein PFC0760c-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small GTPases promote actin coat formation on microsporidian pathogens traversing the apical membrane of Caenorhabditis elegans intestinal cells. Szumowski SC, et al. Cell Microbiol, 2016 Jan. PMID 26147591, Free PMC Article
    2. Orsay δ Protein Is Required for Nonlytic Viral Egress. Yuan W, et al. J Virol, 2018 Jul 15. PMID 29743360, Free PMC Article
    3. ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation. MacQueen AJ, et al. Mol Biol Cell, 2005 Jul. PMID 15872090, Free PMC Article
    4. Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction. Egge N, et al. Dev Cell, 2019 Dec 2. PMID 31794717, Free PMC Article
    5. Non-lytic, actin-based exit of intracellular parasites from C. elegans intestinal cells. Estes KA, et al. PLoS Pathog, 2011 Sep. PMID 21949650, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-onset ACT-5 phosphorylation within its troponin binding site destabilizes actin networks.
      Title: Age-Onset Phosphorylation of a Minor Actin Variant Promotes Intestinal Barrier Dysfunction.
    2. Act-5 has a microvillus-specific function
      Title: ACT-5 is an essential Caenorhabditis elegans actin required for intestinal microvilli formation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in larval feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of eating behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tube formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microvillar actin bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in terminal web IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Actin
    NP_499809.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13604412..13606066 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067408.7 → NP_499809.1  Actin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O45815
      Conserved Domains (2) summary
      smart00268
      Location:6 → 375
      ACTIN; Actin
      cl17037
      Location:1 → 375
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version

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