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    mai-2 ATPase inhibitor mai-2, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 177106, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mai-2
    Official Full Name
    ATPase inhibitor mai-2, mitochondrial
    Primary source
    WormBase:WBGene00015248
    Locus tag
    CELE_B0546.1
    See related
    AllianceGenome:WB:WBGene00015248
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables ATPase inhibitor activity. Predicted to be involved in erythrocyte differentiation and heme biosynthetic process. Located in mitochondrion. Is expressed in several structures, including hypodermis; intestine; nervous system; rectal gland cell; and reproductive system. Orthologous to human ATP5IF1 (ATP synthase inhibitory factor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mai-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (3385910..3386901)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene SRR1 domain-containing protein;Yippee domain-containing protein Neighboring gene Protein yippee-like B0546.4 Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans ATPase inhibitor factor 1 (IF1) MAI-2 preserves the mitochondrial membrane potential (Δψm) and is important to induce germ cell apoptosis. Fernández-Cárdenas LP, et al. PLoS One, 2017. PMID 28829773, Free PMC Article
    2. Caenorhabditis elegans MAI-1 protein, which is similar to mitochondrial ATPase inhibitor (IF1), can inhibit yeast F0F1-ATPase but cannot be transported to yeast mitochondria. Ichikawa N, et al. J Bioenerg Biomembr, 2006 Apr. PMID 16897438
    3. Autofluorescence as a noninvasive biomarker of senescence and advanced glycation end products in Caenorhabditis elegans. Komura T, et al. NPJ Aging Mech Dis, 2021 Jun 7. PMID 34099724, Free PMC Article
    4. Bacterial peptidoglycan muropeptides benefit mitochondrial homeostasis and animal physiology by acting as ATP synthase agonists. Tian D, et al. Dev Cell, 2022 Feb 7. PMID 35045336, Free PMC Article
    5. LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans. Pandey T, et al. Cell Rep, 2024 Mar 26. PMID 38446666, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATPase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of ATP-dependent activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of nucleotide metabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATPase inhibitor mai-2, mitochondrial
    NP_500336.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      3385910..3386901
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067935.9 → NP_500336.1  ATPase inhibitor mai-2, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O44441
      Conserved Domains (1) summary
      pfam04568
      Location:36 → 85
      IATP; Mitochondrial ATPase inhibitor, IATP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O44441.1

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