U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ser-7 G-protein coupled receptors family 1 profile domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180565, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ser-7
    Official Full Name
    G-protein coupled receptors family 1 profile domain-containing protein
    Primary source
    WormBase:WBGene00004780
    Locus tag
    CELE_C09B7.1
    See related
    AllianceGenome:WB:WBGene00004780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled serotonin receptor activity and neurotransmitter receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and chemical synaptic transmission. Located in membrane. Is expressed in egg-laying apparatus; intestine; and nervous system. Human ortholog(s) of this gene implicated in alcohol use disorder. Orthologous to human HTR7 (5-hydroxytryptamine receptor 7). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ser-7 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (2673572..2682384)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene PDEase domain-containing protein;Secreted protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MICOS complex subunit MIC60-1 Neighboring gene ncRNA Neighboring gene Membrane-associated protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SER-7b, a constitutively active Galphas coupled 5-HT7-like receptor expressed in the Caenorhabditis elegans M4 pharyngeal motorneuron. Hobson RJ, et al. J Neurochem, 2003 Oct. PMID 12969249
    2. Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans. Gomez-Amaro RL, et al. Genetics, 2015 Jun. PMID 25903497, Free PMC Article
    3. Serotonin-induced stereospecific formation and bioactivity of the eicosanoid 17,18-epoxyeicosatetraenoic acid in the regulation of pharyngeal pumping of C. elegans. Zhou Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2023 May. PMID 36914111
    4. Recognition of familiar food activates feeding via an endocrine serotonin signal in Caenorhabditis elegans. Song BM, et al. Elife, 2013 Feb 5. PMID 23390589, Free PMC Article
    5. Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans. Song BM, et al. J Neurosci, 2012 Feb 8. PMID 22323705, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Localization of SER-7b in the M4 pharyngeal motorneuron suggests that SER-7b may play a role in the regulation of pharyngeal pumping.
      Title: SER-7b, a constitutively active Galphas coupled 5-HT7-like receptor expressed in the Caenorhabditis elegans M4 pharyngeal motorneuron.
    2. Serotonin separately activates pumping and isthmus peristalsis mainly by activating 5-HT-7 serotonin receptor in motor neurons in response to bacteria.
      Title: Serotonin activates overall feeding by activating two separate neural pathways in Caenorhabditis elegans.
    3. SER-4 and SER-7 were found to be involved in ethanol-mediated gustatory plasticity in Caenorhabditis elegans
      Title: Ethanol interferes with gustatory plasticity in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled amine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    G-protein coupled receptors family 1 profile domain-containing protein
    NP_001024373.1
    • Confirmed by transcript evidence
    NP_741730.1
    • Confirmed by transcript evidence
    NP_741731.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      2673572..2682384
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171637.6 → NP_741730.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741730.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22895
      Conserved Domains (1) summary
      cd15329
      Location:42 → 382
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_171941.7 → NP_741731.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T3C1
      Conserved Domains (1) summary
      cd15329
      Location:42 → 382
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001029202.6 → NP_001024373.1  G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024373.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86GT6
      Conserved Domains (1) summary
      cd15329
      Location:42 → 382
      7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous