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    ges-1 Gut esterase 1 [ Caenorhabditis elegans ]

    Gene ID: 178633, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ges-1
    Official Full Name
    Gut esterase 1
    Primary source
    WormBase:WBGene00001578
    Locus tag
    CELE_R12A1.4
    See related
    AllianceGenome:WB:WBGene00001578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables carboxylesterase activity. Involved in cellular catabolic process. Located in peroxisome. Is expressed in intestine and pharynx. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ges-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (1427653..1432137, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BPTI/Kunitz inhibitor domain-containing protein;Kunitz/Bovine pancreatic trypsin inhibitor domain protein Neighboring gene pseudo Neighboring gene Facilitated glucose transporter homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bifunctional glyoxylate cycle protein of Caenorhabditis elegans: a developmentally regulated protein of intestine and muscle. Liu F, et al. Dev Biol, 1995 Jun. PMID 7781887
    2. In vivo function of mutated spliced leader RNAs in Caenorhabditis elegans. Xie H, et al. Proc Natl Acad Sci U S A, 1998 Apr 14. PMID 9539720, Free PMC Article
    3. Production of null mutants in the major intestinal esterase gene (ges-1) of the nematode Caenorhabditis elegans. McGhee JD, et al. Genetics, 1990 Jul. PMID 2379823, Free PMC Article
    4. The novel nematicide wact-86 interacts with aldicarb to kill nematodes. Burns AR, et al. PLoS Negl Trop Dis, 2017 Apr. PMID 28379972, Free PMC Article
    5. In Vivo Delivery and Activation of Masked Fluorogenic Hydrolase Substrates by Endogenous Hydrolases in C. elegans. Dube S, et al. Chembiochem, 2017 Sep 19. PMID 28703362, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables carboxylesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carboxylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gut esterase 1
    NP_503411.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1427653..1432137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071010.8 → NP_503411.1  Gut esterase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503411.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O16702, Q04457
      Conserved Domains (2) summary
      COG0657
      Location:100 → 211
      Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
      pfam00135
      Location:18 → 535
      COesterase; Carboxylesterase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04457.1

    Gene LinkOut

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