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    apm-3 AP-3 complex subunit mu [ Caenorhabditis elegans ]

    Gene ID: 186194, updated on 9-Dec-2024

    Summary

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    Official Symbol
    apm-3
    Official Full Name
    AP-3 complex subunit mu
    Primary source
    WormBase:WBGene00000164
    Locus tag
    CELE_F53H8.1
    See related
    AllianceGenome:WB:WBGene00000164
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in lipid storage and lysosome organization. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in cytoplasmic vesicle. Is expressed in several structures, including muscle cell; nervous system; pharynx; spermatheca; and vulva. Orthologous to several human genes including AP3M1 (adaptor related protein complex 3 subunit mu 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See apm-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (954975..957762)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Phosphatidylcholine:ceramide cholinephosphotransferase 2 Neighboring gene Beta-arrestin arr-1 Neighboring gene Chitinase domain-containing protein 1 Neighboring gene Neuronal calcium sensor 1 Neighboring gene Neuropeptide-Like Protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widespread organisation of C. elegans genes into operons: fact or function? Nimmo R, et al. Bioessays, 2002 Nov. PMID 12386927
    2. miR-51 regulates GABAergic synapses by targeting Rab GEF GLO-4 and lysosomal trafficking-related GLO/AP-3 pathway in Caenorhabditis elegans. Zhang S, et al. Dev Biol, 2018 Apr 1. PMID 29476722
    3. The AP-3 clathrin-associated complex is essential for embryonic and larval development in Caenorhabditis elegans. Shim J, et al. Mol Cells, 2005 Jun 30. PMID 15995364
    4. Role of the Caenorhabditis elegans multidrug resistance gene, mrp-4, in gut granule differentiation. Currie E, et al. Genetics, 2007 Nov. PMID 17947407, Free PMC Article
    5. C. elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1. Grill B, et al. Neuron, 2007 Aug 16. PMID 17698012

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of clathrin adaptor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    AP-3 complex subunit mu
    NP_508184.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      954975..957762
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075783.7 → NP_508184.2  AP-3 complex subunit mu [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508184.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q20736
      Conserved Domains (2) summary
      cd09252
      Location:165 → 413
      AP-3_Mu3_Cterm; C-terminal domain of medium Mu3 subunit in adaptor protein (AP) complex AP-3
      cd14837
      Location:3 → 141
      AP3_Mu_N; AP-3 complex subunit mu N-terminal domain
    Nucleotide Protein
    Heading Accession and Version

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