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    hsp-12.6 SHSP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hsp-12.6
    Official Full Name
    SHSP domain-containing protein
    Primary source
    WormBase:WBGene00002013
    Locus tag
    CELE_F38E11.2
    See related
    AllianceGenome:WB:WBGene00002013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables identical protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in cytoplasm. Is expressed in hypodermis; intestine; muscle cell; sperm; and spermatid. Human ortholog(s) of this gene implicated in cataract 16 multiple types; cataract 9 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hsp-12.6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (9446229..9447228, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SHSP domain-containing protein Neighboring gene ncRNA Neighboring gene PAN domain protein Neighboring gene Amidohydrolase-related domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Investigating hookworm genomes by comparative analysis of two Ancylostoma species. Mitreva M, et al. BMC Genomics, 2005 Apr 26. PMID 15854223, Free PMC Article
    2. Confocal spectrofluorimetric evidence for the hetero-aggregation of sequence-scrambled forms of two model all-beta sheet proteins. Shukla A, et al. Int J Biol Macromol, 2007 Dec 1. PMID 17707903
    3. Unique structural features of a novel class of small heat shock proteins. Leroux MR, et al. J Biol Chem, 1997 May 9. PMID 9139746
    4. Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer's Disease. Wang H, et al. Neurotox Res, 2021 Jun. PMID 33400180
    5. Association of several small heat-shock proteins with reproductive tissues in the nematode Caenorhabditis elegans. Ding L, et al. Biochem J, 2000 Oct 1. PMID 11001875, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Caenorhabditis elegans 12-kDa small heat shock proteins with little in vitro chaperone activity play crucial roles for its dauer formation, longevity, and reproduction.
      Title: The Caenorhabditis elegans 12-kDa small heat shock proteins with little in vitro chaperone activity play crucial roles for its dauer formation, longevity, and reproduction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables unfolded protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to heat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SHSP domain-containing protein
    NP_501668.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9446229..9447228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069267.4 → NP_501668.1  SHSP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501668.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE36
      Conserved Domains (1) summary
      cd06526
      Location:27 → 108
      metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
    Nucleotide Protein
    Heading Accession and Version

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