bas-1 Aromatic-L-amino-acid decarboxylase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: bas-1
Official Full Name: Aromatic-L-amino-acid decarboxylase
Primary source: WormBase:WBGene00000239
Locus tag: CELE_C05D2.4
See related: AllianceGenome:WB:WBGene00000239
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable L-dopa decarboxylase activity. Involved in several processes, including dopamine biosynthetic process from tyrosine; egg-laying behavior; and turning behavior involved in mating. Predicted to be active in cytoplasm. Is expressed in dopaminergic neurons; serotonergic neurons; socket cell; tail; and in male. Used to study nicotine dependence. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See bas-1 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 8

Sequence:: Chromosome: III; NC_003281.10 (5612274..5614660)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

bas-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
Title: Ethanol interferes with gustatory plasticity in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C05D2.4 (e-PCR)
- UniSTS:308469

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-dopa decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables aromatic-L-amino-acid decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine biosynthetic process from tyrosine	IDA Inferred from Direct Assay more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory perception of chemical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in turning behavior involved in mating	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Aromatic-L-amino-acid decarboxylase

NP_001021150.1

Confirmed by transcript evidence

NP_001021151.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

5612274..5614660

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001025980.6 → NP_001021151.1 Aromatic-L-amino-acid decarboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021151.1

Status: REVIEWED

UniProtKB/TrEMBL

O45137, Q66NI3

Conserved Domains (1) summary

cl18945
Location:35 → 461

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
NM_001025979.5 → NP_001021150.1 Aromatic-L-amino-acid decarboxylase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001021150.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KYG4, Q66NI4

Conserved Domains (1) summary

cl18945
Location:35 → 452

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...